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Here we report a cooperative Nano-CRISPR scaffold (Nano-CD) that utilizes a specific sgRNA, selected from a functional screen for triggering endogenous GDSME expression, while releasing cisplatin to initiate immunologic cell death.

2023年2月11日 · Here we present a cooperative Nano-CRISPR scaffold (Nano-CD), self-supplying GSDME, developed for intracellular pyroptosis-based immunotherapy. Briefly, Nano-CD is fabricated by coating a...

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2023年2月11日，四川大学华西医院巩长旸等合作在《Nature Communiactions》上发表了研究论文，研究人员构建了一个合作的Nano-CRISPR支架（Nano-CD），该支架利用从功能筛选中选择的特定sgRNA来触发内源性GDSME表达，同时释放顺铂以激发免疫细胞死亡。

Shengzhen University Topics:Quality Assessment, Low-level Vision, Large Multi-modality Models, GAME AI - Nano-cd

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