The crosstalk of NAD, ROS and autophagy in cellular health
2020年3月3日 · NAD is an essential metabolite that participates in cellular energy generation and signalling. When plentiful, the redox balance and availability of NAD aid cellular adaptation to metabolic stress and help maintain genomic stability, mitochondrial function, detoxification of ROS and cell survival (Fang et al. 2017).
NAD
2021年1月1日 · Gomes et al. suggested that ROS production increases due to NAD + reduction during aging and promotes hypoxia-inducible factor-1α (HIF-1α) accumulation, leading to metabolic reprogramming,...
Structure and mechanisms of ROS generation by NADPH oxidases
2019年12月1日 · ROS are generated by a heme cofactor through an uncommon outer sphere mechanism. Prolonged NOXs activity can ultimately lead to fibrosis-related diseases, such as cancer and muscular dystrophy. NADPH oxidases (NOXs) are integral membrane enzymes that produce reactive oxygen species.
Oxidation of NADH and ROS production by respiratory complex I
2016年7月1日 · Oxygen reduction to superoxide and (or) hydrogen peroxide by complex I is described. Physiological significance of mitochondrial ROS production is critically evaluated. Kinetic characteristics of the proton-pumping NADH:quinone …
Role of NAD + -Modulated Mitochondrial Free Radical Generation …
2020年7月14日 · In this review we will discuss the mechanisms of mitochondrial free radical production following ischemic insult, mechanisms that protect mitochondria against free radical damage, and the impact of post-ischemic nicotinamide adenine mononucleotide (NAD +) catabolism on mitochondrial protein acetylation that affects ROS generation and ...
NADPH oxidases: an overview from structure to innate immunity ...
2014年9月29日 · Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are lethal to...
Changing ROS, NAD and AMP: A path to longevity via …
2023年1月1日 · Using substances that able to target mitochondria, as well as allotopic expression of specific enzymes, are envisioned to be innovative approaches to prolong lifespan by modulation of ROS, NAD +, and AMP levels.
NADPH 氧化酶和线粒体之间的对话：在 ROS 信号传导和血管生成 …
Reactive oxygen species (ROS) derived from NADPH oxidase (NOX) as well as mitochondria play an important role in promoting the angiogenic switch from quiescent endothelial cells (ECs). However, how highly diffusible ROS produced from different sources and location can communicate with each other to regulate angiogenesis remains unclear.
Nature：揭秘钠离子控制线粒体呼吸链中缺氧信号的分子机制 - 生 …
研究者Hernansanz说道，我们发现，钠离子能扮演一种次级信号来调节线粒体的功能，尤其是通过诱导活性氧的受控产生来调节线粒体电子传递链（ETC）的功能；活性氧产生的机制针对肺循环对缺氧所产生反应的能力非常重要，而肺循环会将血液重新分配到“灌溉”量较少的区域，这种现象称之为缺氧性肺血管收缩（hypoxic pulmonary vasoconstriction， HPV）。
NADPH氧化酶与ROS信号区域化 - pku.edu.cn
最近有关活性氧物质 (ROS)的研究取得了突飞猛进的进展,尤其是其作为第二信使介导了许多生理性与病理性细胞事件,包括细胞分化、过度生长、增殖及凋亡.为了避免ROS的毒性产生特异性的信号转导,ROS的产生与代谢必须被严格调控;其具体的调控机制一直是人们 ...