2021年11月14日 · Under optimized conditions (DMF, 0 °C, 1 h), N - (tosylmethyl)ureas smoothly reacted with NaCN (1.10–1.10 equiv.) to give α-ureido nitriles. According to DFT computational data, the first step of cyanide-anion amidoalkylation with N - (tosylmethyl)ureas involves the formation of the corresponding N -acylimines under the action of CN-anion ...

2016年2月21日 · 要：氰基化合物因具有独特的性质被人们广泛的应用在医药、农药、材料等领域。 系统地介绍了有机合成中的加氰反. 应，对不同类型的氰化反应进行了综述。 1．Hebei Chengxin Co．. Ltd．. anation in organic synthesis．. 及强吸电子性质。 它能够深入到靶标蛋白深处与活. 性部位的关键氨基酸残基形成氢键相互作用。 代表的含氰基医药品种包括沙格列汀、维拉. 虫苯甲酰胺、氟啶虫酰胺等。 此外，氰基化合物在. 香料、功能材料等领域也具有重要的 …

If a halogenoalkane is heated under reflux with a solution of sodium or potassium cyanide in ethanol, the halogen is replaced by a -CN group and a nitrile is produced. Heating under reflux means heating with a condenser placed vertically in the flask to prevent loss of volatile substances from the mixture. The solvent is important.

2005年1月3日 · The cyanide-ring opening of thionocarbonates with NaCN in DMF and TBACN in THF is described. This reaction occurred regioselectively to afford β-hydroxy nitrile with preserved stereochemistry of the hydroxy group in high yield.

Reaction of cyclopentadienyliron (CpFe) complexes of chlorobenzenes with NaCN in DMF could give rise to products resulting from the addition of the cyanide ion or from substitution and addition reactions with the cyanide ion.

2021年5月6日 · How does the reaction of Alkyl Halides with sodium nitrite in DMF proceed? I was aware of the reaction of alkyl halides with aqueous sodium nitrite which results in the formation of an alkyl nitri...

2011年2月5日 · Reaction of cyclopentadienyliron (CpFe) complexes of chlorobenzenes with NaCN in DMF could give rise to products resulting from the addition of the cyanide ion or from substitution and...

2016年1月13日 · Bearing in mind the subsequent reaction, the decarboxylation was tested in DMF, which was a good solvent in the palladium-catalyzed carbonylation for the synthesis of benzoylacetonitriles. We found that NaCN, NaCl, and LiCl provided lower yields of the product than they did in DMSO (entries 6–8).

2023年10月11日 · In the given reaction, sodium cyanide (NaCN) reacts in dimethylformamide (DMF) to produce methylamine (CH3NH2) and TsOH (p-toluenesulfonic acid) acting as a catalyst. The reaction is an example of a nucleophilic substitution reaction, specifically an SN2 reaction.

2018年12月26日 · Correct option (c) N, N' - dimethylformamide (DMF) Explanation : The reaction, CH3CH2CH2Br + NaCN → CH3CH2CH2CN + NaBr follows SN2 mechanism which is favoured by polar aprotic solvent i.e.. N, N' - dimethylformamide (DMF),