2021年10月26日 · Next, hypoxia causes a transcriptional upregulation of Nr3c1 in human renal proximal tubular epithelial cells (Leonard et al, 2005) and mouse pituitary AtT‐20 cells (Zhang …

2022年11月1日 · Since the primary role of metabolic regulation by glucocorticoids is to respond to stress, the expression of NR3C1 closely follows that of HIF1A, which induces the hypoxic …

2021年12月6日 · Here we demonstrate a previously undescribed tumor cell-intrinsic role for GR in activating PD-L1 expression and repressing the major histocompatibility complex class I (MHC …

Hypoxia significantly increased CpG methylation at the CREs and Sp1 binding sites and decreased transcription factor binding to GR exon 1 promoter, accounting for the repression of …

2019年1月17日 · Our data supports the hypothesis that Nr3c1 influences DNA methylation at birth and that DNA methylation in placenta correlates with adult frontal cortex DNA methylation and …

2005年2月15日 · The actions of glucocorticoids are mediated through an intracellular receptor, the glucocorticoid receptor (GR, 3 NR3C1), which is a member of the nuclear receptor family of …

2023年1月14日 · NR3C1 amplification, along with IL-6 and SRPX suppressions, were detected in tumor. High stromal score and enriched infiltrated aDCs and B cells in the high-risk group …

Importantly, NR3C1 has previously been shown to promote the formation of memory precursor T cells and can be upregulated by hypoxia (38, 39). In addition, there was considerable overlap …

2015年5月25日 · The NR3C1 construct with the major allele, C′ of SNP rs10482612 (NR3C1-1.1), resembling the most commonly found wild type, was compared to the minor wild type with the …

2021年7月8日 · In the first step, dexamethasone induces the transcription factor (TF) NR3C1 (Nuclear Receptor Subfamily 3 group C member 1). It has been demonstrated that the NR3C1 …