Together with the phagocyte NADPH oxidase itself (NOX2/gp91 (phox)), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS).

2021年6月1日 · The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first identified in the membrane of phagocytic cells. For many years, its only known role was in immune defense, where its ROS production leads to …

2024年6月6日 · 烟酰胺腺嘌呤二核苷酸磷酸氧化酶 (NOX) 是一种产生活性氧 (ROS) 的酶，最初在吞噬细胞膜中被发现。 它的主要作用是在免疫防御中，通过产生 ROS 来破坏病原体。

2023年1月20日 · Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS, the superoxide anion radical (O2·-) is a key redox signaling molecule prominently generated by the NADPH oxidase (NOX) …

2025年3月18日 · 一、ROS与铁死亡间的关联 在认识NOX家族之前，我们先了解一下NOX介导生成的产物ROS的定义及功能。 ROS是指由氧衍生的小分子物质，包括氧自由基如超氧（O2-）、羟基（•OH）、过氧（RO2•）、烷氧基（RO•）和某些非自由基。

2019年12月1日 · Consistent with their role as second messengers, ROS are deliberately produced by enzymes, the NADPH oxidases (NOXs), in response to specific physiological stimuli. Together with mitochondrial enzymes of the respiratory chain, NOXs are recognized as the main source of ROS in cells.

2014年11月1日 · Nox-derived ROS contribute to chemical modification of molecules involved in hormone formation and matrix modification, to host defense, to redox signaling, and probably many other events [1].

2023年1月20日 · ROS scavengers or NOX inhibitors significantly suppress PCB118-induced glucose consumption, lactate production, and aerobic glycolysis-related gene expression, thereby supporting the key role of NOX-dependent ROS generation in the glucose metabolism reprogramming of these cells [33].

2023年9月27日 · NADPH氧化酶（NOX）信号通路：NOX家族成员在细胞膜上催化还原态氧分子生成超氧阴离子（O2^-），从而产生其他ROS。 这些ROS可以激活一系列复杂的信号传导分子，如蛋白激酶C（PKC）和丝裂原活化蛋白激酶（MAPK），介导细胞凋亡、炎症反应等过程。

2014年9月29日 · The key producers of ROS in many cells are the NOX family of NADPH oxidases, of which there are seven members, with various tissue distributions and activation mechanisms.