2016年4月21日 · Here we show that NOD1 and NOD2, two members of the NOD-like receptor family of PRRs, are important mediators of ER-stress-induced inflammation in mouse and human cells. The ER stress inducers thapsigargin and dithiothreitol trigger production of the pro-inflammatory cytokine IL-6 in a NOD1/2-dependent fashion.

NOD1 and NOD2 have been implicated in ER stress-induced inflammation either directly, by sensing the disruption in ER homeostasis, or indirectly, via ER stress-mediated processes such as autophagy, mitophagy and increases in intracellular calcium concentration.

2022年3月10日 · Functional studies show that VCP controlled ER stress induces inflammatory responses in a NOD2-dependent fashion; thus, providing a new potential mechanistic link and therapeutic target in...

The newly proposed function of NOD2 in orchestrating IRE1α-induced inflammatory responses (Keestra-Gounder et al., 2016) now provides a plausible explanation, because influenza virus is known to trigger ER stress (Roberson et al., 2012).

Surprisingly, two intracellular innate immune receptors, NOD1 and NOD2, previously shown to sense bacterial peptidoglycan, were found to transduce ER stress signals to elicit inflammation. Given the known roles of both ER stress and NOD2 in chronic inflammatory diseases, including inflammatory bowel disease and type 2 diabetes, this new link ...

2019年12月24日 · In this primary human MDM study, we found that LACC1 localized to the ER with NOD2 stimulation, associated with ER-stress sensors, and was required for NOD2-induced ER stress, which then mediated a broad range of immune outcomes, including MAPK and NF-κB signaling, and cytokine secretion, as well as bacterial clearance through bacterial uptake ...

2016年6月20日 · NOD1 and NOD2, two members of the intracellular NOD-like receptor family, sense bacterial peptidoglycan-derived fragments and induce pro-inflammatory responses. Recent work provides evidence for a role for NOD1/NOD2 signaling in mediating ER-stress-induced inflammatory responses via a peptidoglycan-independent mechanism.

2019年12月24日 · We find that upon stimulation of the pattern-recognition receptor (PRR) NOD2, LACC1 localizes to the endoplasmic reticulum (ER) and forms a complex with ER-stress sensors. All three ER-stress branches, PERK, IRE1α, and ATF6, are required for NOD2-induced signaling, cytokines, and antimicrobial pathways in human macrophages.

2016年3月23日 · Here we show that NOD1 and NOD2, two members of the NOD-like receptor family of PRRs, are important mediators of ER-stress-induced inflammation in mouse and human cells. The ER stress...

2025年1月13日 · ER stress inhibitor reduced Grp78 and NOD2 expression in colitis model mice and alleviated colitis. ER stress inducer cooperated with NOD2 ligand MDP to upregulate TNF-α, IL-8 and IL-1β, and activate MAPK signaling in THP-1 cells.