NLR family pyrin domain containing 3 (NLRP3) (previously known as NACHT, LRR, and PYD domains-containing protein 3 [NALP3] and cryopyrin), is a protein that in humans is encoded by the NLRP3 gene [5] located on the long arm of chromosome 1.

2021年5月20日 · NLRP3为NOD样受体热蛋白结构域相关蛋白3（NOD-like receptor thermal protein domain associated protein 3, NLRP3），是NOD样受体家族中重要的一员，其炎性小体复合物由NLRP3、凋亡相关斑点样蛋白（apoptosis-ass…

2019年4月29日 · NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and environmental irritants,...

2024年7月1日 · Abnormal NLRP3 induction results in the reconfiguration of myocytes and ultimately leads to improper function and the release of damaged mitochondrial DNA that binds to NLRP3.

nlrp3是一种炎症小体传感器蛋白，在许多疾病中都进行过大量的研究。 激活NLRP3会产生包括ASC与Caspase-1等在内的寡聚体复合物。 该寡聚体蛋白复合物被称为“炎症小体(Inflammasone)”，当复合物中的传感器蛋白为NLRP…

The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage. However, the aberrant ...

2025年2月10日 · Structural analysis suggested multiple mechanisms by which CAPS variants activate NLRP3, including enhanced ATP binding, stabilizing the active NLRP3 conformation, destabilizing the inactive...

nlrp3 (nlrp3)靶点介绍助您了解其蛋白功能，蛋白定位，蛋白表达及异构体和翻译后修饰等特性。 同时列举了实用的WB实验小贴士，助您实验成功。 NLRP3 (NLRP3)靶点介绍及实验小贴士| Abcam中文官网

NLRP3是一种三重蛋白，由氨基末端pyrin结构域（PYD）、中心核苷酸结合和低聚结构域（NOD；又称 NACHT结构域 ）和C末端富含亮氨酸重复序列（LRR）结构域组成。NLRP3的pyrin结构域与ASC的pyrin结构域相互作用，启动炎症小体组装。

2025年3月30日 · Complete information for NLRP3 gene (Protein Coding), NLR Family Pyrin Domain Containing 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium