NKp46（NCR1，CD335）是人类NK细胞的主要激活受体，一种46kDa的糖蛋白，由两个C2型的胞外Ig样结构域组成，属于免疫球蛋白（Ig）超家族。 NKp46主要在静止和激活的NK细胞、ILC1、粘膜中ILC3的一个亚群（NCR+ ILC3）和一小部分T淋巴细胞上表达。 NKp46在哺乳动物中高度保守，并在NK细胞裂解自体、异体或异种细胞中发挥作用。 NKp46的触发主要通过其与含有免疫受体酪氨酸激活基序（ITAM）的分子 CD3ζ 和 FcRγ 的关联来介导信号传递，诱导蛋白酪氨酸 …

2025年1月24日 · NKp46 is a critical regulator of natural killer (NK) cell immunity, but its function in non-NK innate immune cells remains unclear. Here, we show that NKp46 is indispensable for expressing IL-2...

We report here the generation of trifunctional natural killer (NK) cell engagers (NKCEs), targeting two activating receptors, NKp46 and CD16, on NK cells and a tumor antigen on cancer cells. Trifunctional NKCEs were more potent in vitro than clinical therapeutic antibodies targeting the same tumor antigen.

2023年4月5日 · NKp46 recognition of the P domain of ecto-CRT triggers NK cell signalling and NKp46 caps with ecto-CRT in NK immune synapses. NKp46-mediated killing is inhibited by knockout or knockdown of...

2024年11月29日 · NKp46 is a natural killer cell activating receptor primarily expressed on NK cells and non-NK innate lymphoid cells. In the context of anti-infection, NKp46 activates NK cells by binding to ligands on pathogens or infected cells, enabling NK cells to kill the infected cells.

自然细胞毒性受体（ncr）包括nkp46、nkp30 和nkp44，三者均为 免疫球蛋白超家族 （igsf）成员，但彼此无 同源性 。ncr 只表达于nk细胞表面，是nk 细胞特有的标志，通常在kir/klr 丧失识别“自我”能力时发挥杀伤作用。

2023年11月2日 · The NKp46 receptor, encoded by the Ncr1 gene, plays an important role in NK cells. Non-NK immune cells, including ILC1s also express NKp46. However, the role of NKp46 in these non-NK immune cells remains largely unknown.

NKp46 is a novel triggering receptor expressed by all human NK cells that is involved in natural cytotoxicity. In this study we show that the surface density of NKp46 may vary in different NK cells and that a precise correlation exists between the NKp46 phenotype of …

NKp46 (NCR1，CD335)是由两个C2型胞外Ig样结构域组成的46kDa糖蛋白，与NKp30和NKp44同属自然细胞毒性受体 (NCR)，是 免疫球蛋白 (Ig) 超家族成员。 NKp46特异表达于静止和激活的NK细胞表面和一小部分T淋巴细胞上，NKp46是人类NK细胞标志物，在哺乳动物中高度保，它参与NK细胞对自体、异体和异种细胞的裂解。 作为激动性靶点，NKp46以HLA1类分子非依赖方式诱导NK细胞活化直接杀伤靶细胞。 NKp46通过与含有ITAM的 CD3ζ 和FcRγ分子结合诱导信号传 …

Two of these triggering receptors, the NKp46 natural cytotoxicity receptor (NKp46) and the major histocompatibility complex (MHC) class I-interactive NKG2D receptor, are deficiently expressed by NK cells recovered from patients with acute myeloid leukaemia (AML), but little is known regarding the regulation of NKp46 and NKG2D expression.