2016年3月21日 · Among the 14-3-3 proteins, 14-3-3ɛ serves a crucial function in antiviral immunity by mediating the cytosol–to–mitochondrial membrane translocation of the pathogen sensor RIG-I. Here we found that...

Among the 14-3-3 proteins, 14-3-3ɛ serves a crucial function in antiviral immunity by mediating the cytosol-to-mitochondrial membrane translocation of the pathogen sensor RIG-I. Here we found that the NS3 protein of dengue virus (DV) bound to 14-3-3ɛ and prevented translocation of RIG-I to the adaptor MAVS and thereby blocked antiviral signaling.

14-3-3 proteins regulate biological processes by binding to phosphorylated serine or phosphorylated threonine motifs of cellular proteins. Among the 14-3-3 proteins, 14-3-3 serves …

Here we show that the NS3 protein of dengue virus (DV) binds to 14-3-3ε and prevents RIG-I translocation to the adaptor MAVS, thereby blocking antiviral signaling. Intriguingly, a highly conserved phosphomimetic Rx E P motif in NS3 is essential for 14-3-3ε binding.

1999年2月1日 · Using this approach we develop reliable interatomic potentials for Al and Ni. The potentials accurately reproduce basic equilibrium properties of these metals, the elastic constants, the phonon-dispersion curves, the vacancy formation and migration energies, the stacking fault energies, and the surface energies.

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Dengue is an arthropod borne viral infection that is listed as a neglected tropical disease (Wilder-Smith et al., 2019). It is one of the major health threats globally and has experienced a massive increase in incidents over the past half century. However, no …

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