2021年3月15日 · Nerve growth factor (NGF) gene therapy has been used in clinical trials of Alzheimer’s disease. Understanding the underlying mechanisms of how NGF influences...

1993年8月10日 · We measured the activities of UDP-galactose:globotriaosylceramide alpha 1-3-galactosyltransferase (alpha-GalTase) and protein kinase C (PKC) in PC12D pheochromocytoma (PC12D) cells which were induced to differentiation by nerve growth factor (NGF), forskolin (FRK), staurosporine (STP), retinoic acid …

Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. NGF promotes neuritis ...

2021年2月15日 · In this study, the modulatory effect of exogenous nerve growth factor (NGF) on mesenchymal stem/stromal cell (MSC) functions and the paracrine effects of MSC-derived NGF on other cell types are discu...

1999年9月9日 · Here we present the crystal structure of human NGF in complex with human TrkA-d5 at 2.2 Å resolution. The ligand–receptor interface consists of two patches of similar size. One patch involves the...

神经生长因子（NGF）是神经营养因子家族中的核心成员，其发现和研究始于上世纪中叶，由意大利科学家Levi-Montalcini等人率先报道。 NGF的发现，不仅为神经科学领域的研究开辟了新的方向，也为后续的神经生长因子家族成员的研究奠定了基础。

2021年2月15日 · The effects of nerve growth factor (NGF) and its two receptors, TrkA and p75NTR, on neural cells are well studied. Increasing evidence shows that NGF, TrkA, and p75NTR are also involved in various aspects of MSC function, including their survival, growth, differentiation, and angiogenesis.

This article considers expanded roles for NGF that are associated with the dynamically regulated production of NGF and its receptors that begins in development, extends throughout adult life and aging, and involves a surprising variety of neurons, glia, and nonneural cells.

2018年3月2日 · Single nucleotide polymorphisms in NGF gene (rs6330) and NGFR gene (rs2072446 and rs734194) are associated with the disease. Furthermore, it was shown that the carriage of the NGF rs6330*T minor allele is associated with increased infarct volume and higher risk of recurrent stroke.

2018年9月27日 · ngf/trka通路一方面直接诱导trpv1的通道致敏和减小其通道打开的阈值，另一方面，ngf还可以调控信号转录，增加trpv1的表达和跨膜，进一步降低伤害感受神经元动作电位产生的阈值，从而增加痛感 。