Apr 15, 2024 · Here we report that nerve growth factor receptor (NGFR) is upregulated in skeletal cells during OA and plays an essential role in the remodeling and repair of...

In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA development.

Nov 20, 2020 · Chronic pain from osteoarthritis (OA) is highly prevalent, and effective non-opioid medications are few. Nerve growth factor (NGF) is an important neurotrophin that activates nociceptive...

Jul 26, 2021 · Associations between anti-NGF antibody therapy and rapidly progressive OA have prompted research into alternative approaches to target NGF that have improved safety …

In this review, we aimed to give an update on the current clinical and preclinical studies targeting two pathways that are being investigated for treating OA pain: the nerve growth factor (NGF) pathway and the transient receptor potential vanilloid-1 (TRPV1) pathway.

We present the effects of dose, administration mode, and treatment duration on the efficacy and safety of anti-NGF antibody therapy. There were 19 RCTs included in our meta-analysis.

To evaluate the efficacy and safety of anti-NGF antibody treatment in hip and knee osteoarthritis (OA), a systematic review and meta-analysis was undertaken utilizing the criteria described by the Cochrane collaboration.

Jan 1, 2015 · To evaluate the efficacy and safety of anti-NGF antibody treatment in hip and knee osteoarthritis (OA), a systematic review and meta-analysis was undertaken utilizing the criteria described by the Cochrane collaboration.

Jan 17, 2018 · NGF blockade is an attractive target for analgesia, and several companies have developed humanized mAb that bind NGF with high specificity and affinity, preventing it from binding its receptor. These antibodies include tanezumab (Pfizer and Eli Lilly), fasinumab (Regeneron and Teva) and fulranumab (Janssen and Amgen).

Aug 1, 2017 · In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA development.