Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described.

Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. NGF promotes neuritis ...

Since its discovery, nerve growth factor (NGF) has long occupied a critical role in developmental and adult neuro-biology for its many important regulatory functions on the survival, growth and differentiation of nerve cells in the peripheral and ...

The discovery of nerve growth factor (NGF) more than 60 years ago is associated with embryonal development and the differentiation of peripheral neuronal cells. Studies by Levi-Montalcini in chick embryos clearly demonstrated that the production of this diffusible factor in the target organ was responsible for the survival of peripheral neurons ...

part 4：痛觉神经与cafs的“恶性循环”——ngf-cgrp正反馈. 关键发现4：cafs通过ngf反哺痛觉神经. 双向调控：cafs分泌的ngf进一步促进痛觉神经元释放cgrp，形成ngf-cgrp-il-15-nk细胞的正反馈环路。 治疗意义：联合靶向ngf（如抗ngf抗体）和cgrp可能增强疗效。

2012年11月29日 · The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocrine and immune systems.

2021年1月18日 · Nerve Growth Factor (NGF) promotes wound-healing and regulates ECM remodeling, allowing a well-balanced tissue repair and recovery of functional activity 4,5.

Nerve growth factor (NGF) is largely known as a target-derived factor responsible for the survival and maintenance of the phenotype of specific subsets of peripheral neurones and basal forebrain cholinergic nuclei during development and maturation. However, NGF also exerts a modulatory role on sensory, nociceptive nerve physiology during ...

2018年3月9日 · NGF differentiation involves the induction of P-AMPK and P-CaMK, and is prevented by their pharmacological inhibition. These molecular events correlate with modifications of energy and redox...

Nerve growth factor (NGF) is a protein necessary for the differentiation and maintenance of peripheral sympathetic neurons, certain sensory neurons, and cholinergic neurons of the basal forebrain. NGF is synthesized in target areas of NGF-responsive neurons. This protein binds to specific cell surfa …