NF-κB 亚基的激活导致它们的核易位和转录激活；NF-κB 通路可调节许多基因的转录，包括促炎细胞因子和趋化因子 (如 IL-6)、细胞周期基因 (如 cyclin D1)、抗凋亡基因 (如 bcl-2) 和胞外蛋白酶 (如 MMP3) 等。

2010年5月1日 · The ultimate consequence of NF-kappaB signalling is the activation of inflammatory genes including adhesion molecules and chemotaxins. However, clinically, the hallmark of vascular NF-kappaB activation is the production of interleukin-6 (IL-6), whose local role in vascular inflammation is relatively unknown.

2023年3月30日 · 经典NF-kB通路[1]：快而短暂的转录激活作用（促炎因子），由多种因素诱导如炎症、免疫反应、细胞增殖、分化以及存活。 IκBα磷酸化激活与降解，p65/p50入核，促进炎症因子产生（IL1β、TNF-α、IL-6等） 非经典NF-…

The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of …

这些受体下游的 NFκB 和 IRF途径 可诱导促炎性细胞因子 TNF-α 、 IL-1β 和IL-6的表达。 这些细胞因子具有广泛的生物学活性，有助于协调机体对感染的反应。 IL-1β是IL-1家族中的重要成员，由于其在炎症相关疾病中的重要作用而备受关注。 IL-1β具有较强的促炎活性，可诱导多种促炎介质，如细胞因子和趋化因子。 IL-1β具有多种功能。 它对各种细胞有多种作用，并最终导致广泛的炎症事件。 全身而言，IL-1β信号传导可导致 急性期反应 、低血压、血管扩张和发热。 局部而 …

2003年9月15日 · We show that IL-6 receptors are present in intestinal epithelia in a polarized fashion. Basolateral IL-6 and, to a lesser extent, apical IL-6 induces the activation of the NF-kappaB pathway. Basolateral IL-6 stimulation results in a maximal induction of NF-kappaB activation and NF-kappaB nuclear translocation at 2 h. IL-6 induces polarized ...

Here, we found that during the early phase of lipopolysaccharide (LPS) stimulation, NF-κB and an NF-κB-triggered IL-6-positive feedback loop activate Arid5a gene expression, increasing IL-6 expression via stabilization of the IL-6 mRNA.

2020年2月15日 · NF-κB binding activity was investigated in order to examine whether IL-6 imposes an immediate or delayed activation of the NF-κB signaling pathway. We found that IL-6 administration did not significantly affect NF-κB binding to its target DNA at early time points (0–2 h), whereas NF-κB binding activity was increased at 6 h, indicating ...

2004年5月28日 · Our data demonstrate that the p65 subunit of NF-κB cotransfected with the −80 IL-6 promoter-reporter gene construct containing only the TATA box and the κB site is unable to induce luciferase activity by itself, while it strongly synergizes with C/EBPδ and/or c …

2010年3月3日 · The ultimate consequence of NF-κB signalling is the activation of inflammatory genes including adhesion molecules and chemotaxins. However, clinically, the hallmark of vascular NF-κB activation is the production of interleukin-6 (IL-6), whose local role in vascular inflammation is relatively unknown.