Mar 28, 2020 · 在所有E3连接酶中，它们的开启开关（on-switch）中的大约三分之一是一种类似于泛素的小蛋白，即NEDD8。 NEDD8控制对其他蛋白的关闭

除cullin家族外，NEDD8还有多种底物，控制多种生物过程。 NEDD化可以抑制抗癌蛋白p53，激活癌蛋白MDM2，调控EGFR、Parkin/PINK1、HIF1α/HIF2α、Caspases/IAPs/RIP1、Histone …

Mar 30, 2025 · NEDD8 (NEDD8 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with NEDD8 include Malignant Astrocytoma and Parkinson's Disease. Among its …

Apr 5, 2024 · NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

NEDD8 is a protein that in humans is encoded by the NEDD8 gene. [5][6] (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently …

拟素化修饰（Neddylation） 是近年来发现的新型蛋白质翻译后修饰，可以广泛地调节生物学过程，如细胞周期、信号传导和免疫识别等。 泛素样蛋白 NEDD8 通过类似泛素化的过程与目标 …

Oct 12, 2021 · NEDD8 is best known for its function as a stimulator of cullin-RING ligases (CRLs) via neddylation of cullin family proteins 4, 5. It also modifies many other proteins, though the …

Here we show that p27 ubiquitination in HeLa cell extract requires the ubiquitin-like protein Nedd8 and enzymes that catalyze Nedd8 conjugation to proteins. Furthermore, we show that …

Here, we review the NEDD8 pathway, its importance in cancer, and the therapeutic potential of NAE inhibition. Keywords: NEDD8, ubiquitin, cullin-RING ligase, DNA rereplication Introduction

Oct 22, 2018 · Spatial management of stress-induced protein aggregation is an integral part of the proteostasis network. Protein modification by the ubiquitin-like molecule NEDD8 increases …