2024年4月5日 · NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein …

Inactivation of the Nedd8 conjugation pathway by a dominant negative mutant of the Nedd8-conjugating enzyme Nce1/Ubc12 blocks the ubiquitination and degradation of p27 in cell …

Here, we review the NEDD8 pathway, its importance in cancer, and the therapeutic potential of NAE inhibition. Keywords: NEDD8, ubiquitin, cullin-RING ligase, DNA rereplication.

2021年10月12日 · Here, the authors identify similarities and differences of ubiquitin and NEDD8 phosphorylation, showing that phosphorylated NEDD8 has a distinct interactome and …

NEDD8 is a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin RING ligases. Many non-cullin neddylation targets have been proposed in recent years. …

2025年3月30日 · NEDD8 (NEDD8 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with NEDD8 include Malignant Astrocytoma and Parkinson's Disease . Among its …

NEDD8 /RUB1 (NEDD8) is an 8 kDa protein that is closely related to ubiquitin. Just like ubiquitin, NEDD8 can be conjugated to proteins (neddylation). Unlike ubiquitin, however, NEDD8 does …

2024年4月27日 · We reveal that NEDD8 loss in cancer cells causes a vulnerability to nivolumab (anti-PD-1). Genetic deletion of NEDD8 only delays cell division initially but cell proliferation is …

2019年4月3日 · Neddylation is a process of conjugating NEDD8, an ubiquitin-like molecule, to targeted protein substrates via enzymatic cascades involving NEDD8-activating enzyme E1, …

Here, we review the NEDD8 pathway, its importance in cancer, and the therapeutic potential of NAE inhibition. Keywords: DNA rereplication; NEDD8; cullin-RING ligase; ubiquitin. Cancer …