2025年3月30日 · NCR1 (Natural Cytotoxicity Triggering Receptor 1) is a Protein Coding gene. Diseases associated with NCR1 include Gestational Trophoblastic Neoplasm and Hydatidiform Mole, Recurrent, 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene. [5] [6] NCR1 has also been designated as CD335 (cluster of differentiation, NKP46, NKp46, NK-p46, and LY94. [7]

This gene has 8 transcripts (splice variants), 1 gene allele, 86 orthologues and 25 paralogues. Biased expression in spleen (RPKM 1.6), bone marrow (RPKM 0.4) and 12 other tissues. 功能概要

NCR1，即自然细胞毒性触发受体1，别名NKp46、CD335、LY94。它是一种免疫球蛋白超家族成员，具有两个细胞外免疫球蛋白样域，属于I型跨膜受体。NCR1由人类19号染色体上的基因编码，位于Leukocyte Receptor Complex (LRC) 区域。

Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral natural killer cells. NKp46 cleavage by Cathepsin G severely impairs NKp46-mediated responses of Natural killer cells. The NKp46 and NKp46-ligand interaction contributes to NK cell activation.

2018年9月17日 · NKG2D and NCR1 are activating receptors expressed on all NK cells. They primarily mediate tissue stress surveillance by recognizing stress-induced self-ligands on target cells 4. NCR1 (NKp46)...

2024年11月2日 · NKp46 is selectively expressed in aggressive subtypes of primary Gastrointestinal T-cell lymphoma.

2004年11月15日 · The C. elegans genome contains two homologs of NPC1, ncr-1 and ncr-2, and an ncr-2;ncr-1 double deletion mutant forms dauer larvae constitutively (Daf-c). We have analyzed the phenotypes of ncr single and double mutants in detail, and determined the ncr gene expression patterns.

Activating receptors include NKG2D, DNAM-1 and the natural cytotoxicity receptors (NCRs) family, the latter being composed of three molecules: NCR1 (NKp46), NCR-2 (NKp44) and NCR-3 (NKp30) . NCR1 was the first NCR isolated and is a type I-transmembrane receptor that contains 2 Ig-domains and that associates with either CD3ζ or FcμRIγ in ...

Using activating receptor natural cytotoxicity receptor (NCR) 1 deficient (NCR1 gfp/gfp) mice, we found increased numbers of virus-specific CD8 T cells, leading to enhanced virus control during acute LCMV infection.