Pathology Outlines - Plasma cell myeloma (multiple myeloma)
2022年5月26日 · In the diagnosis of smoldering myeloma the patient may have M protein in serum (IgG or IgA) at ≥ 3 g/dL or Bence Jones protein ≥ 500 mg/24 h urine or 10 - 59% clonal plasma cells in bone marrow. Clonal plasma cells in the setting of multiple myeloma are typically negative for CD19.
Multiple Myeloma - Pathology - Orthobullets
2022年5月6日 · Multiple Myeloma is neoplastic proliferation of plasma cells that commonly results in multiple skeletal lesions, hypercalcemia, renal insufficiency, and anemia. Patients typically present at ages > 40 with localized bone pain or a pathologic fracture. Diagnosis is made with a bone marrow biopsy showing monoclonal plasma cells ≥10%.
The histopathology of myeloma in the bone marrow - PMC
Myeloma cells are classified into four types: mature, immature, pleomorphic, and plasmablastic. There are three patterns in which myeloma infiltrates bone marrow - nodular, interstitial, and diffuse. Dutcher bodies are highly specific to neoplastic myeloma cells. On immunohistochemical staining, the specificity of CD138 is high for plasma cells.
Multiple Myeloma - LearnHaem | Haematology Made Simple
Multiple myeloma is characterised by the proliferation of clonal plasma cells, usually resulting in the production of a paraprotein and end-organ damage. The diagnostic criteria for multiple myeloma were set out by the International Myeloma Working Group in …
CD138− plasma cell myeloma | Blood - American Society of …
2019年9月12日 · Recognizing the presence of CD138 − PCM combined with morphology and other plasma cell markers, such as CD38 and MUM1, will be helpful for a correct diagnosis. For additional images, visit the ASH Image Bank, a reference and teaching tool that is continually updated with new atlas and case study images.
Assessment of bone marrow plasma cell infiltrates in multiple myeloma ...
Based on the CD138 staining in the 79 cases with multiple myeloma included in the study, we identified 4 distinct morphologic patterns of plasma cell distribution, similar to what was reported in previous studies using κ and λ light chain IHC .
BCMA Versus CD138 for Identifying Multiple Myeloma on Flow …
2017年12月7日 · In this study, our aim was to compare BCMA (CD269) to CD138 in its ability to detect MM cells in flow cytometric analysis, in order to determine whether or not BCMA should be included in standard MM flow cytometry panels.
Expression of multiple myeloma specific markers in bone marrow …
Multiple myeloma (MM) is a malignant B cell tumor originating from pre switched, follicle center B lymphocytes which differentiate into plasma cells that accumulate in the bone marrow (Bergsagel and Kuehl 2001).
In this work, we address stain color normalization and cell segmentation from microscopic images stained with Jenner-Giemsa stain for multiple myeloma (MM). Images were captured from the slides of patients with MM and stained using Jenner-Giemsa stain.
Plasma cell myeloma: role of histopathology, …
2021年3月9日 · Bone marrow trephine core biopsies allow for the histologic assessment of myeloma disease burden and can be used for immunohistochemistry or RNA in situ hybridization staining. Bone marrow aspirates are preferred for genetic testing, including FISH and next-generation sequencing (NGS)–based assays, which require non-decalcified tissue.