The protein encoded by the Trim63 gene is also called MuRF1. MuRF1 is the name most commonly used in the literature, and it stands for "Muscle RING Finger 1." Structurally, there …

2019年5月1日 · The muscle RING-finger protein-1 (MuRF1) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. …

MuRF1 (TRIM63) is a muscle-specific E3 ubiquitin ligase and component of the ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that cause …

2020年9月11日 · The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play important roles during skeletal muscle atrophy. Since then, numerous …

2024年3月1日 · The data presented here offers molecular insight into MuRF-induced ubiquitylation. We show that MuRF1 can interact with the UBE2D, E, N/V families and UBE2W …

2023年5月13日 · Herein, we investigate the requirement of the muscle-specific E3 ubiquitin ligase, MuRF1, for muscle wasting induced by pancreatic cancer. Murine pancreatic cancer …

骨骼肌萎缩是多种疾病的并发症之一,其机制可归因于蛋白质降解增加与合成受阻.近年来,人们发现蛋白质降解增加与肌肉环状指基因1(MuRF1)和肌肉萎缩盒F基因(MAFbx,atrogin-1)的表达增加 …

2019年3月27日 · In the present study, we hypothesized that MuRF1, a key gene involved in skeletal muscle mass loss, and its close counterpart MuRF2 play a role in skeletal muscle …

MuRF1 is a member of the RBCC (RING, B-box, coiled-coil) superfamily that has been proposed to act as an atrogin during muscle wasting. Here, we show that MuRF1 is preferentially …

MuRF1 is a member of the RBCC (RING, B-box, coiled-coil) superfamily that has been proposed to act as an atrogin during muscle wasting. Here, we show that MuRF1 is preferentially …