MTHFD2 in healthy and cancer cells: Canonical and non-canonical ...
Mar 15, 2024 · MTHFD2 has become a highly attractive therapeutic target due to its consistent upregulation in cancer tissues and its major contribution to tumor progression, although it also …
MTHFD2 Gene - GeneCards | MTDC Protein | MTDC Antibody
Mar 30, 2025 · MTHFD2 (Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase) is a Protein Coding gene. Diseases associated with …
MTHFD2 is a metabolic checkpoint controlling effector and
Jan 11, 2022 · We show that the one-carbon (1C) metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) regulates de novo purine synthesis and signaling in activated T …
Mitochondrial Methylene Tetrahydrofolate Dehydrogenase (MTHFD2 …
The mitochondrial counterpart of MTHFD2 has now been identified as MTHFD2L. This enzyme uses NADP as a cofactor and unlike MTHFD2, is expressed at low levels in early mouse …
The folate-coupled enzyme MTHFD2 is a nuclear protein and
Oct 13, 2015 · Although the enzymatic activity of the MTHFD2 protein is well understood, little is known about its larger role in cancer cell biology. We here report that MTHFD2 is co …
MTHFD2 is a metabolic checkpoint controlling effector and regulatory …
Jan 11, 2022 · We show that the one-carbon (1C) metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) regulates de novo purine synthesis and signaling in activated T …
Targeting mitochondrial one-carbon enzyme MTHFD2 together …
Jul 5, 2022 · MTHFD2, a mitochondrial one-carbon metabolic enzyme, is dysregulated in several malignancies and may serve as a promising therapeutic candidate in cancer treatment.
More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for ... - PubMed
Apr 28, 2020 · This review summarizes current knowledge on both the metabolic functions and non-enzymatic roles of MTHFD2. Its expression, potential functions, and regulatory …
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP
Jan 4, 2025 · MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway. Up-regulation of MTHFD2 is associated with clinicopathological …
The folate cycle enzyme MTHFD2 induces cancer immune evasion ... - PubMed
Mar 29, 2021 · Here we perform a functional screen of metabolic genes that rescue tumour cells from effector T cell cytotoxicity, and identify the embryo- and tumour-specific folate cycle …
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