2025年3月30日 · MTHFD2 (Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase) is a Protein Coding gene. Diseases associated with MTHFD2 include Hematologic Cancer and Spina Bifida. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and One-carbon metabolism and related …

2024年3月15日 · MTHFD2 has become a highly attractive therapeutic target due to its consistent upregulation in cancer tissues and its major contribution to tumor progression, although it also performs vital...

2022年1月11日 · We show that the one-carbon (1C) metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) regulates de novo purine synthesis and signaling in activated T cells to promote proliferation and inflammatory cytokine production.

The mitochondrial counterpart of MTHFD2 has now been identified as MTHFD2L. This enzyme uses NADP as a cofactor and unlike MTHFD2, is expressed at low levels in early mouse embryos, increases by day 10.5, and is found in all adult tissues, with highest levels in lung and brain and is likely a housekeeping enzyme.

2015年10月13日 · Although the enzymatic activity of the MTHFD2 protein is well understood, little is known about its larger role in cancer cell biology. We here report that MTHFD2 is co-expressed with two...

2020年4月27日 · MTHFD2 (350 amino acids, 37kDa) is one of the major enzymes involved in mitochondrial folate one-carbon metabolism and is also known as NMDMC (NAD-dependent mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase).

2021年3月29日 · Here we perform a functional screen of metabolic genes that rescue tumour cells from effector T cell cytotoxicity, and identify the embryo- and tumour-specific folate cycle enzyme...

2021年3月29日 · Here we perform a functional screen of metabolic genes that rescue tumour cells from effector T cell cytotoxicity, and identify the embryo- and tumour-specific folate cycle enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2).

2025年1月4日 · MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway. Up-regulation of MTHFD2 is associated with clinicopathological characteristics and poor survival in ovarian cancer, possibly by regulating MOB1A signaling.

2020年4月28日 · This review summarizes current knowledge on both the metabolic functions and non-enzymatic roles of MTHFD2. Its expression, potential functions, and regulatory mechanism in cancers are highlighted. The development of MTHFD2 inhibitors and their implications in pre-clinical models are also discussed.