Cullin 4B-RING E3 ligase negatively regulates the ... - Nature
2024年8月14日 · When stimulated with pro-inflammatory cytokines, MSCs lacking CUL4B display enhanced immunosuppressive capacity, which is mediated by the elevated inducible nitric …
间充质干细胞的免疫调节 - 知乎 - 知乎专栏
随后发现tnf-α和ifn-γ联合刺激bmscs，诱导mscs表达inos产生的no反过来也能诱导mscs的凋亡。 这些实验研究的数据结果表明， NO作为血管舒张的小分子，能诱导淋巴细胞和BMSCs的凋 …
Mesenchymal stem cells: a double-edged sword in regulating …
2012年3月16日 · When inducible nitric oxide synthase (iNOS) production was inhibited or genetically ablated, MSCs strongly enhance T-cell proliferation in vitro and the delayed-type …
Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via …
2008年2月7日 · Our most definitive proof of the central role of NO is that iNOS-deficient MSCs lack immunosuppressive capability. Various studies have shown that MSCs expanded ex vivo …
Mesenchymal Stem Cells Employ IDO to Regulate Immunity in …
To resolve this predicament, we developed a novel strategy to humanize murine MSCs by incorporating the human IDO gene into MSCs derived from mice lacking the iNOS gene (iNOS …
p53 regulates mesenchymal stem cell-mediated tumor …
2013年8月26日 · We have demonstrated that p53 deficiency allows enhanced upregulation of iNOS expression and NO production in MSCs. NO has long been acknowledged as an …
Mesenchymal Stem Cell‐Based Immunomodulation: Properties …
2018年6月14日 · In the presence of proinflammatory cytokines, MSCs facilitate high expression of inducible NO synthase (iNOS), which stimulates the secretion of NO, giving rise to inhibition of …
间充质干细胞与免疫的相互作用_百科TA说 - 百度百科
究其原因，主要是低水平的炎症因子不足以诱导mscs表达高水平inos或ido发挥免疫抑制作用，反而会在mscs分泌大量趋化因子的作用下招募淋巴细胞至其周围，加剧炎症反应。
Time-dependent LPS exposure commands MSC immunoplasticity through …
2020年9月25日 · Our results showed that 1-h LPS exposure induced a MSC1 phenotype. Indeed, MSCs-LPS1h expressed low levels of NO/iNOS and decreased immunosuppressive capacity …
Mesenchymal stem cells use IDO to regulate immunity in tumor ...
2014年3月1日 · To address this issue, we established a novel humanized system to model human MSCs, using murine iNOS (-/-) MSCs that constitutively or inducibly express an ectopic human …