MRE11A - Wikipedia
Double-strand break repair protein MRE11 (Meiotic recombination 11) is an enzyme that in humans is encoded by the MRE11 gene. [5] The gene has been designated MRE11A to distinguish it from the pseudogene MRE11B that is nowadays named MRE11P1.
MRE11 Gene - GeneCards | MRE11 Protein | MRE11 Antibody
2024年12月25日 · MRE11 (MRE11 Homolog, Double Strand Break Repair Nuclease) is a Protein Coding gene. Diseases associated with MRE11 include Ataxia-Telangiectasia-Like Disorder 1 and Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia .
Nature重磅|揭示MRE11从核小体封锁中释放cGAS从而预防癌症产 …
2024年1月16日 · mre11功能的破坏会导致dna损伤耐受、免疫抑制并加速肿瘤发生。mre11促进dsdna激活cgas的新功能独立于其核酸酶活性和atm信号传导。 mrn复合物 与核小体片段的结合从核小体ap表面释放cgas，这使得cgas能够动员、细胞质重新定位并被dsdna激活。这些mre11依赖 …
The MRE11 complex: starting from the ends - Nature
2011年1月21日 · The MRE11 complex, consisting of meiotic recombination 11 (MRE11), RAD50 and Nijmegen breakage syndrome 1 (NBS1; also known as nibrin), is of key importance in the DNA damage response to DNA...
Metabolic regulation of homologous recombination repair by MRE11 …
2023年12月20日 · Herein, we demonstrate that MRE11, a crucial homologous recombination (HR) protein, is lactylated at K673 by the CBP acetyltransferase in response to DNA damage and dependent on ATM phosphorylation of the latter. MRE11 lactylation promotes its binding to DNA, facilitating DNA end resection and HR.
MRE11 liberates cGAS from nucleosome sequestration during
2024年1月10日 · We demonstrate that binding of the MRE11–RAD50–NBN complex to nucleosome fragments is necessary to displace cGAS from acidic-patch-mediated sequestration, which enables its mobilization and...
Mre11: roles in DNA repair beyond homologous recombination
2009年7月26日 · The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now, several new studies reveal that Mre11 also has a role in mammalian...
MRE11 as a molecular signature and therapeutic target for …
2021年8月28日 · MRE11, the core of the MRE11/RAD50/NBS1 complex, is one of key DNA damage response proteins. Increasing evidence suggests that its expression in cancer cells is critical to developing radioresistance; as such, MRE11 is an emerging marker for targeted radiosensitization strategies.
MRE11 MRE11 homolog, double strand break repair nuclease
Mre11 stabilizes Nbs1 and Rad50 and MRN activates Chk2 downstream from ATM in response to replication-mediated DNA double strand breaks; MRE11 is a new common target in the mismatch repair deficient tumorigenesis and has a role in colorectal carcinogenesis; Functional and structural characterization of a nuclease-deficient Mre11 protein termed ...
MRE11 同系物，双链断裂修复核酸酶（MRE11）基因 | MCE
mre11 同系物，双链断裂修复核酸酶： 该基因编码一种参与同源重组、端粒长度维持和 dna 双链断裂修复的核蛋白。 该蛋白质本身具有 3' 至 5' 核酸外切酶活性和核酸内切酶活性。