2024年8月1日 · This brief overview seeks to clarify the difference between C4A and C4a and to aid in the interpretation of the C4A and C4a changes observed in psychosis. The complement system comprises three pathways activated by distinct mechanisms: classical (CP), lectin (LP) and alternative pathway (AP).

Complement plays a pivotal role in the pathogenesis of multiple sclerosis. C4a, an activated fragment of complement component C4, has been linked to disease activity. We correlated plasma C4 and plasma and CSF C4a with clinical disease in a well-characterised cohort of patients and controls.

C4a, an activated fragment of complement component C4, has been linked to disease activity. We correlated plasma C4 and plasma and CSF C4a with clinical disease in a well-characterised cohort of patients and controls. Plasma C4 was non-significantly and CSF C4a was significantly elevated overall in patients compared to controls.

Massive parallel signature sequencing (MPSS) is a procedure that is used to identify and quantify mRNA transcripts, resulting in data similar to serial analysis of gene expression (SAGE), although it employs a series of biochemical and sequencing steps that are substantially different.

We summarized current knowledge related to the role of C4, C4A, and C4B CNVs in SLE and other systemic autoimmune diseases and determined whether C4 genes are a genetic master key to autoimmunity. Subgroup analyses focusing on disease type and ethnicity were conducted to investigate potential sources of heterogeneity in the included studies.

2024年6月11日 · 2 Department of Psychiatry, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, Ireland. Keywords: C4A; Complement C4; Complement system; Psychosis; Schizophrenia.

2023年7月18日 · The complement component 4 gene locus, composed of the C4A and C4B genes and located on chromosome 6, encodes for C4 protein, a key intermediate in the classical and lectin pathways of the complement system. The complement system is an important ...

This structural variation generates varying levels of C4 RNA expression, and genetic information from the MHC region can now be used to predict C4 RNA expression in the brain. Increased predicted C4A RNA expression is associated with the risk of SZ, and C4 is reported to influence synaptic pruning in animal models.

MPSS技术是利用限制性内切酶和荧光检测知识,发展出的一种辨认和测定细胞每一个cDNA 克隆片段末端16～20bp序列的方法,从而查明细胞内所有基因的表达情况。

C4a, a small protein fragment produced during the activation of the complement system, plays a crucial role in immune regulation and inflammation. Although its activity is less pronounced than other anaphylatoxins like C3a and C5a, C4a has distinct biological functions that contribute to the body's defense mechanisms and homeostasis.