MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene. [5] [6] Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling ...

2021年6月10日 · MPP5, capable of generating MPP1-4 but not HSCs, represents a dynamic and versatile component of the MPP network. To characterize all hematopoietic stem and progenitor cells, we performed RNA-sequencing (RNA-seq) analysis to identify specific transcriptomic landscapes of HSCs and MPP1-5.

2021年6月10日 · Transplanted MPP5 is important for emergency myelopoiesis and long-term lymphoid reconstitution. Hematopoietic stem cells (HSCs) and distinct multipotent progenitor (MPP) populations (MPP1-4) contained within the Lin − Sca-1 + c-Kit + (LSK) compartment have previously been identified using diverse surface-marker panels.

课题将构建肝脏特异性MPP5敲除小鼠，运用三维细胞培养，比较基因组杂交，质谱分析方法实现目标：1）明确MPP5在肝癌中异常表达的原因，2）探索MPP5调节YAP功能的分子机制，3）发现MPP5抑制肝癌的生物学效应。 结果将揭露MPP5在肝癌中的功能，发现YAP上游调控机制,为肝癌发病机制的理解和新靶点的研发提供基础。 ，国自然项目查询平台，国家自然基金结果查询.

Chromosome 14: 67,707,826-67,802,536 forward strand. This gene has 7 transcripts (splice variants), 11 paralogues and is associated with 1 phenotype. Sorry, the page request "/Homo_sapiens/Component/Gene/Summary/gene_summary?g=ENSG00000072415;r=14:67707826-67802536;db=core;time=1743654085465.465" failed to load.

2025年1月14日 · In summary, MPP5 facilitates the nuclear exclusion of YAP and TAZ in liver cancer. This qualifies MPP5 as a potential tumor-suppressor gene and explains how changes in cell polarity can foster tumorigenesis. Keywords: Crumbs complex; HCC; Hippo pathway; apical polarity; tumor-suppressor gene.

2021年8月1日 · MPP5, capable of generating MPP1-4 but not HSCs, represents a dynamic and versatile component of the MPP network. To characterize all hematopoietic stem and progenitor cells, we performed RNA-sequencing (RNA-seq) analysis to identify specific transcriptomic landscapes of HSCs and MPP1-5.

2023年6月1日 · Newly characterized MPP5 population contains high proportion of EPCR-expressing cells. Ageing mediates preferential expansion of EPCR hi HSCs. Endothelial protein C receptor (EPCR) has emerged as one of the most conserved and reliable surface markers for the prospective identification and isolation of hematopoietic stem cells (HSCs).

MAGUK p55 subfamily member 5is a protein in humans that is encoded by MPP5 gene. May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter.

MPP5, also named as PALS1, belongs to the MAGUK family which interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. MPP5 is thought to organize intracellular PALS1-CRB-MUPP1 protein scaffolds in the retina that are involved in maintenance of photoreceptor-Mu¨ller glia cell adhesion.