2016年8月1日 · To identify and characterize monoubiquitinated proteasomal substrates, the authors silenced expression of endogenous wild-type ubiquitin and expressed a …

2001年3月1日 · Recently, monoubiquitin has emerged as a regulator of the location and activity of diverse cellular proteins. Histone regulation: Core histones H2A and H2B and the linker …

2006年10月1日 · Ubiquitin receptors themselves are frequently monoubiquitinated by a process that requires the presence of a UBD and is referred to as coupled monoubiquitination. Using a …

Ubiquitin can be covalently attached to target proteins as a single moiety (monoubiquitin), as multiple single moieties (multiple monoubiquitin), as chains coupled through the same Lys …

Some proteins are modified by a single ubiquitin or short ubiquitin chains. Instead of sending proteins to their death through the proteasome, monoubiquitylation regulates processes that …

2010年6月11日 · Monoubiquitination regulates the capacity of Rpn10 to interact with substrates by inhibiting Rpn10's ubiquitin-interacting motif (UIM). We show that Rsp5, a member of …

Ubiquitin is a 76-amino acid protein whose conjugation to protein targets is a form of post-translational modification. Protein ubiquitylation is characterized by the covalent attachment of …

2022年5月25日 · Monoubiquitination is a post-translational modification (PTM), through which a single ubiquitin molecule is covalently conjugated to a lysine residue of the target protein. …

Monoubiquitination can regulate DNA repair, viral budding and gene expression, while polyubiquitination through K48 of Ub generally results in proteasomal degradation, and K63 …

Post-translational modification of proteins with ubiquitin regulates a variety of eukaryotic cellular processes. Ubiquitin can be conjugated to substrates either as a single moiety …