2024年12月25日 · MON2 (MON2 Homolog, Regulator Of Endosome-To-Golgi Trafficking) is a Protein Coding gene. Diseases associated with MON2 include Hypogonadotropic Hypogonadism 14 With Or Without Anosmia. Gene Ontology (GO) annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An …

67074 Ensembl ENSG00000061987 ENSMUSG00000034602 UniProt Q7Z3U7 Q80TL7 RefSeq (mRNA) NM_001278469 NM_001278470 NM_001278471 NM_001278472 NM_015026 NM_001163024 NM_001163025 NM_153395 RefSeq (protein) NP_001265398 NP_001265399 NP_001265400 NP_001265401 NP_055841 NP_001265400.1 NP_001156496 NP_001156497 NP_700444 Location (UCSC) Chr 12: 62.47 – 62.6 Mb Chr 10: 122.83 – 122.91 Mb PubMed ...

2021年12月3日 · MON-2, a protein localized to the trans-Golgi network, was initially identified in a genetic screen for hypersensitivity against monensin and brefeldin A, which are inhibitors of vesicular transport in cells (3). MON-2 mediates trafficking between subcellular organelles, including the Golgi and endosome.

通过采用定量蛋白质组学方法，我们证明了 mon-2 是一种进化上保守的 arf-gef 蛋白，涉及高尔基体到内体的运输，通过上调秀丽隐杆线虫中的巨自噬/自噬来促进长寿. 我们使用培养的哺乳动物细胞的数据表明，mon2 在饥饿条件下从高尔基体转移到核内体，随后通过 ...

By employing a quantitative proteomic approach, we demonstrated that MON-2, an evolutionarily conserved Arf-GEF protein implicated in Golgi-to-endosome trafficking, promotes longevity via upregulating macroautophagy/autophagy in C. elegans. Our data using cultured mammalian cells indicate that MON2 translocates from the Golgi to the endosome ...

Using a quantitative proteomic approach, we found that a Golgi protein, MON-2, was up-regulated in long-lived Caenorhabditis elegans mutants with mitochondrial respiration defects and was required for their longevity. Similarly, we showed that DOP1/PAD-1, which acts with MON-2 to traffic macromolecules between the Golgi and endosome ...

2016年9月14日 · Gene target information for MON2 - MON2 homolog, regulator of endosome-to-Golgi trafficking (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2022年2月19日 · By employing a quantitative proteomic approach, we demonstrated that MON-2, an evolutionarily conserved Arf-GEF protein implicated in Golgi-to-endosome trafficking, promotes longevity via upregulating macroautophagy/autophagy in C. elegans.

Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.

By employing a quantitative proteomic approach, we demonstrated that MON-2, an evolutionarily conserved Arf-GEF protein implicated in Golgi-to-endosome trafficking, promotes longevity via ...