Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin -based cytoskeletons .

To elucidate the structural basis of possible mechanisms, we generated informative moesin mutations and tested three attributes: membrane localization of the expressed moesin, moesin binding to PIP2, and PIP2-induced release of moesin autoinhibition.

2025年3月30日 · MSN (Moesin) is a Protein Coding gene. Diseases associated with MSN include Immunodeficiency 50 and Verrucous Carcinoma. Among its related pathways are Sensory processing of sound and Interleukin-12 family signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and actin binding.

Background and aims: Moesin, an ezrin/radixin/moesin family member, is involved in the regulation of cell adhesion, polarity, and migration by cross-linking between the actin cytoskeleton and plasma membrane.

Moesin, an EMT driver, is elevated in cells harboring disease-associated phosphotau, over-stabilized actin, and ectopic cell cycle activation. We further find that genetic manipulation of Moesin mediates tau-induced neurodegeneration. Taken together, our study identifies novel parallels between tauopathy and cancer.

Moesin, an ezrin-radixin-moesin (ERM) family member, is involved in the regulation of cell adhesion, polarity and migration by cross-linking between the actin cytoskeleton and plasma membrane. The primary effector cell in hepatic fibrosis is the ...

Moesin. Moesin is an ABP involved in paracellular gap formation but also in wound healing by inducing cell migration in HUVEC . Proteomic analysis of HUVEC after stimulation with LPS for 24 h revealed that moesin was secreted into supernatants . Notably, moesin levels also increased in a time-dependent fashion in sera of mice with lethal sepsis ...

Moesin deficiency is an X-linked immunodeficiency associated with lymphopenia, neutropenia, and recurrent bacterial infections. Prolonged or severe varicella virus infections have been described in several affected individuals.

Moesin is a cytoskeletal protein that belongs to the ezrin-radixin-moesin family. It is primarily expressed in lymphocytes and is involved in maintaining cell shape. Mutations in the moesin gene can cause Moesin Deficiency, a combined immunodeficiency disorder characterized by T cell lymphopenia, hypogammaglobulinemia, antibody deficiency, and ...

2021年11月21日 · Moesin is a member of the ezrin-radixin-moesin (ERM) family of proteins that link plasma membrane proteins with actin filaments in the cell cortex. Hemizygous mutations in the X-linked moesin gene are associated with primary immunodeficiency with T and B cell lymphopenia, which also affects natural …