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The median preoptic nucleus is located dorsal to the other three nuclei of the preoptic area of the anterior hypothalamus. The hypothalamus is located just beneath the thalamus, the main sensory relay station of the nervous system, and is considered part of the limbic system, which also includes structures such as the hippocampus and the amygdala.

2018年3月6日 · 这项研究揭示出LT中的一种分层组装的口渴通路：MnPO将来自SFO和OVLT的口渴信号整合在一起，并将它们传递到下游的大脑区域，从而诱导饮水行为。 相关研究结果于2018年2月28日在线发表在Nature期刊上，论文标题为“Hierarchical neural architecture underlying thirst regulation”。 在血液补充水分前，抑制性神经元阻止饮水. 该团队还发现另一种参与口渴的急性饱足感（acute satiety）的神经回路。 Oka说，“当你缺水时，你可能会在几秒钟内吞下水， …

Using the in vivo iDISCO method following viral infection of the MnPO or ex vivo biocytin crystal deposition in the MnPO of mouse brain slices, we revealed a strong axonal pathway from the MnPO to the VLPO.

2022年5月9日 · Previous studies suggest that the median preoptic nucleus (MnPO) of the hypothalamus plays an important role in regulating the wake-sleep cycle and, in particular, homeostatic sleep drive. However, the precise cellular phenotypes, targets, and central mechanisms by which the MnPO neurons regulate the wake-sleep cycle remain unknown.

The Median Preoptic Nucleus is a thin elongated nucleus located in the midline lamina terminalis of the anterior wall of the third ventricle. It plays a crucial role in receiving and relaying neural signals related to osmoregulation, body fluid homeostasis, core temperature regulation, sleep-wake cycles, and cardiovascular functions.

Located in the midline anterior wall of the third cerebral ventricle (i.e. the lamina terminalis), the median preoptic nucleus (MnPO) receives a unique set of afferent neural inputs from fore-, mid- and hindbrain. These afferent connections enable it to receive neural signals related to several important aspects of homeostasis.

2015年3月9日 · Located in the midline anterior wall of the third cerebral ventricle (i.e. the lamina terminalis), the median preoptic nucleus (MnPO) receives a unique set of afferent neural inputs from fore-, mid- and hindbrain. These afferent connections enable it to receive neural signals related to several important aspects of homeostasis.

2021年1月1日 · In this regard, the median preoptic nucleus (MnPO), while relatively small in size, has several essential homeostatic roles. In particular, it has a crucial role integrating neural signals from osmoreceptors and hormonal actions on the brain to regulate thirst and antidiuretic hormone secretion, thereby coordinating body fluid homeostasis.

Several identified and potential targets of the MnPO are prominently implicated in the regulation of sleep and arousal, including the LC, DRN, posterior hypothalamus (PH), pLHA and magnocellular basal forebrain (see Jones, 2003, Jones, 2005 for review).