Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which …

Nov 9, 2023 · MMAE实质是去甲基化的奥瑞他汀 E（auristatin E），即N-末端氨基只有一个甲基取代基，而不是像奥瑞他汀 E 本身那样有两个甲基取代基 。MMAE是一种合成抗肿瘤药，其效 …

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used …

Jul 5, 2022 · Tumor-directed antibodies and peptides conjugated to radiosensitizing monomethyl auristatin E (MMAE) specifically produce CD8 T cell dependent durable tumor control of …

Nov 3, 2023 · mmae作为有效载荷在adc药物的开发中很普遍，已在14个批准的adc中有5个使用了mmae（表1）。 在识别和结合表达在癌细胞表面的靶抗原后，ADC通过内吞作用内化，然后 …

什么是mmae？ MMAE（Monomethyl auristatin E），即单甲基奥瑞他汀E，是一种人工合成的海兔毒素类似物，具有强大的抗肿瘤活性。 它通过阻断微管蛋白的聚合来抑制细胞分裂，在癌症 …

To minimize toxicity and maximize efficacy, MMAE is conjugated, via a cleavable peptide linker, to a monoclonal antibody that specifically targets a patient's tumor. The linker is stable in the …

Background: Monomethyl auristatin E (MMAE) has been used as a payload for several Food and Drug Administration (FDA) approved antibody-drug conjugates (ADCs). It is known that MMAE …

Jul 16, 2011 · Monomethyl auristatin E是海兔毒素10的合成衍生物，通过抑制微管蛋白聚合而起到有效的有丝分裂抑制作用。MMAE广泛用作细胞毒性成分制作抗体-药物偶联物(ADCs)以治疗 …

MMAE (Monomethyl auristatin E)是合成的抗肿瘤药。它也是一种能够破坏微管的试剂。