Monomethyl auristatin E - Wikipedia
Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which …
MMAE——ADC的“团宠”毒素 - 知乎 - 知乎专栏
2023年11月9日 · MMAE实质是去甲基化的奥瑞他汀 E（auristatin E），即N-末端氨基只有一个甲基取代基，而不是像奥瑞他汀 E 本身那样有两个甲基取代基 。MMAE是一种合成抗肿瘤药， …
Monomethyl auristatin E (MMAE) | 抗有丝分裂剂 | MCE
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used …
微管破坏有效载荷MMAE介绍 - 知乎 - 知乎专栏
什么是mmae？ MMAE（Monomethyl auristatin E），即单甲基奥瑞他汀E，是一种人工合成的海兔毒素类似物，具有强大的抗肿瘤活性。 它通过阻断微管蛋白的聚合来抑制细胞分裂，在癌症 …
Monomethyl auristatin antibody and peptide drug conjugates for …
2022年7月5日 · Tumor-directed antibodies and peptides conjugated to radiosensitizing monomethyl auristatin E (MMAE) specifically produce CD8 T cell dependent durable tumor …
Monomethyl auristatin E (MMAE), a payload for multiple
Background: Monomethyl auristatin E (MMAE) has been used as a payload for several Food and Drug Administration (FDA) approved antibody-drug conjugates (ADCs). It is known that MMAE …
Monomethyl Auristatin E | C39H67N5O7 | CID 11542188
Monomethyl auristatin E (MMAE) binds to tubulin, blocks tubulin polymerization, and inhibits microtubule formation, which results in both disruption of mitotic spindle assembly and arrest …
MMAE ADC所特有高发的毒性：周围神经病变 - 知乎
2023年11月3日 · mmae作为有效载荷在adc药物的开发中很普遍，已在14个批准的adc中有5个使用了mmae（表1）。 在识别和结合表达在癌细胞表面的靶抗原后，ADC通过内吞作用内化，然 …
Antibody–Drug Conjugate Payloads: MMAE & MMAF
2022年11月3日 · Monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are identified as the best analogs of dolastatin 10, which bind to microtubules and prevent cell …
单甲基奥瑞他汀E的性质与医药应用 - ChemicalBook
2024年6月6日 · 单甲基奥瑞他汀E， 英文名为MonoMethyl auristatin E，简称为简称MMAE，常温常压下为白色至灰白色固体，不溶于水但是可溶于强极性有机溶剂例如二甲基亚砜，N,N-二甲 …