Mitochondrial unfolded protein response - Wikipedia
The mitochondrial unfolded protein response (UPR mt) is a cellular stress response related to the mitochondria. The UPR mt results from unfolded or misfolded proteins in mitochondria beyond the capacity of chaperone proteins to handle them. [1] The UPR mt can occur either in the mitochondrial matrix or in the mitochondrial inner membrane. [1]
The mitochondrial UPR: mechanisms, physiological functions and ...
2017年11月22日 · Cells activate a transcriptional response known as the mitochondrial unfolded protein response (UPRmt) when mitochondrial integrity and function are impaired to promote their recovery.
Mitochondrial unfolded protein response: An emerging …
2021年2月1日 · Mitochondrial unfolded protein response (UPR mt) is a mitochondria stress response, which the transcriptional activation programs of mitochondrial chaperone proteins and proteases are initiated to maintain proteostasis in mitochondria.
A cytosolic surveillance mechanism activates the mitochondrial UPR
2023年6月7日 · Upon proteotoxic stress, mitochondria activate the mitochondrial unfolded protein response (UPR mt), a nuclear transcriptional response that induces mitochondrial chaperones, such as HSPD1, HSPE1...
Mechanisms, regulation and functions of the unfolded protein response ...
2020年5月26日 · The unfolded protein response (UPR) comprises a network of signalling pathways that reprogramme transcription, translation and protein modifications to relieve the load of unfolded or...
Signaling the Mitochondrial Unfolded Protein Response - PMC
The UPR mt is the collective cellular response to increased levels of mitochondrial unfolded or misfolded proteins through the increased transcription of nuclear-encoded genes that act to promote mitochondrial protein folding.
Mitochondrial unfolded protein response (UPRmt): what we …
This stress response is activated by the accumulation of unfolded/misfolded proteins within the mitochondrial matrix, which results in the transmission of a signal to the nucleus to increase the expression of proteases and chaperones to address the abnormal mitochondrial protein load.
Mitochondrial unfolded protein response: A novel pathway in …
2021年6月1日 · Mitochondrial unfolded protein response (mitoUPR) is a mitochondria stress response to maintain mitochondrial proteostasis during stress. Increasing evidence suggests that mitoUPR participates in diverse physiological processes especially metabolism and immunity.
The mitochondrial unfolded protein response, a conserved …
In this review, we focus on the mitochondrial unfolded protein response (UPR mt), a response to proteotoxic stress specifically in mitochondria, an organelle with a wide array of fundamental functions, most notably the harvesting of energy from food and the control of cell death.
The mitochondrial unfolded protein response - synchronizing …
Mitochondrial unfolded protein response (UPR mt) is an emerging adaptive stress response pathway, which ensures optimal quality and function of the mitochondrial proteome. UPR mt internally surveys mitochondrial proteostasis and responds to stress signals by activating an intricate mitochondrial protein quality control (PQC) network [ 5 - 7 ].
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