Mitochondrial biogenesis - Wikipedia
Mitochondrial biogenesis is the process by which cells increase mitochondrial numbers. [1][2] It was first described by John Holloszy in the 1960s, when it was discovered that physical endurance training induced higher mitochondrial content levels, leading to greater glucose uptake by muscles. [3] .
Mitochondrial biogenesis: An update - PubMed
Recently, considerable progress has been made in deciphering mitochondrial biogenesis-related proteins and genes that function in health and in pathology-related circumstances. However, an outlook on the intracellular mechanisms shared by the main players that drive mitochondrial biogenesis machinery is still missing.
Mitochondrial Biogenesis - an overview | ScienceDirect Topics
Mitochondrial biogenesis is the process by which cells generate new mitochondria and, if necessary, increase mitochondrial mass. This process involves coordinated expression of proteins encoded by nuclear and mitochondrial DNA.
Crosstalk between mitochondrial biogenesis and mitophagy to …
2023年10月12日 · Mitochondria have circular DNA (mitochondrial DNA, mtDNA), and mitochondrial biogenesis (mitobiogenesis) involves the replication, transcription, and translation of mtDNA-encoded genes, the interorganelle transport of phospholipids, and the import of nuclear-encoded proteins into mitochondria through the protein translocation machinery of the ...
Mitochondrial Biogenesis - an overview | ScienceDirect Topics
Mitochondrial biogenesis is the process by which new mitochondria are formed by growth and division of pre-existing mitochondria, leading to increased cellular mitochondrial mass. This process, regulated by peroxisome proliferator-activated receptor-gamma (PPARγ) coactivator-1alpha (PGC-1α), involves synthesis of proteins encoded by both the ...
Mitochondrial proteins: from biogenesis to functional networks
2019年1月9日 · Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization. Protein machineries with diverse functions such as protein translocation,...
Mitochondrial Biogenesis - an overview | ScienceDirect Topics
Mitochondrial biogenesis is the process by which a cell synthesizes new mitochondria, accomplished by translation of both nuclear and mitochondrial transcripts as well as replication of mtDNA [5].
Balancing mitochondrial biogenesis and mitophagy to …
2015年8月10日 · Mitochondrial biogenesis and mitochondrial selective autophagy (mitophagy), two opposing cellular pathways, coordinately regulate mitochondrial content to sustain energy metabolism, in...
Mitochondrial biogenesis in health and disease. Molecular and ...
Mitochondrial biogenesis (MB) is the essential mechanism by which cells control the number of mitochondria. Cells respond to different physiologic, metabolic, and pathologic changes by regulating this organelle with high morphological and functional adaptability.
Mitochondrial Biogenesis, Mitochondrial Dynamics, and …
Mitochondrial biogenesis and mitophagy together regulate the quantity and quality of mitochondrial network. To achieve this, actively operated mitochondrial fusion and fission are indispensable. We summarize here that mitochondrial biogenesis, mitophagy, and mitochondrial dynamics contribute to the successful specification and maturation of CMs.