Anti-miRNA oligonucleotides: A comprehensive guide for design
MiRNA-Masking Antisense Oligonucleotides technology (miR-Mask, also known as BlockmiR, target protectors or as target site blockers) relies on an inverted approach: instead of blocking …
The Principles of MiRNA-Masking Antisense Oligonucleotides
2010年1月1日 · MiRNA-masking antisense oligonucleotides technology (miR-mask) is an anti-microRNA antisense oligodeoxyribonucleotide (AMO) approach of a different sort. A standard …
The principles of MiRNA-masking antisense oligonucleotides
MiRNA-masking antisense oligonucleotides technology (miR-mask) is an anti-microRNA antisense oligodeoxyribonucleotide (AMO) approach of a different sort. A standard miR-mask …
miRNA与疾病治疗 － 丁香通
2013年10月6日 · miRNA 屏障（miR-Mask），是与内源性miRNA 的靶基因结合位点完美互补的一条序列，能够与靶基因以更高的亲和力形成二聚体，因此可以阻断内源性miRNA 与其结合位 …
miRNA-Masking Antisense Oligonucleotides Technology
2009年1月1日 · miRNA-Masking Antisense Oligonucleotides Technology (miR-Mask) is an AMO approach of a different sort. A standard miR-Mask is a single-stranded 2′-O-methyl-modified …
miRNA: A Promising Therapeutic Target in Cancer - PMC
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety …
The principles of MiRNA-masking antisense ... - Semantic Scholar
A standard miR-mask is single-stranded 2'-O-methyl-modified oligoribonucleotide (or other chemically modified) that is a 22-nt antisense to a protein-coding mRNA as a target for an …
Regulatory Mechanisms of Epigenetic miRNA Relationships in …
miRNA-masking (miR-mask) applications contain AMO which have been commonly modified with single-chain 2′-O-methyl to increase binding and nuclease activity. miR masks form a 22 …
miRNAs at the heart of the matter | Journal of Molecular Medicine
2008年4月16日 · A miR-Mask is designed to be exactly antisense to the binding site for an endogenous miRNA of interest in 3'UTR of the target mRNA. Once introduced into the cell, the …
miR masks. miR masks are 2 ′ -O-methyl -modified
A strategy of miR masks has been developed to combat the non-specific effects of the anti-miR oligonucleotide technology. miR masks consist of single- stranded, 2 ′ -O-methyl modified...