2025年1月17日 · The microglia balked at spewing out their contents via lysosomal exocytosis, a process in which lysosomes fuse with the plasma membrane to dump their contents outside of the cell (Apr 2023 conference news). Despite their constipation, SORL1-deficient microglia ramped up phagocytosis when fed with fibrillar Aβ, consuming even more of it than ...

2024年7月19日 · Because lipid-accumulating microglia (LAMs) emerge in aging brains and around amyloid plaques, the scientists wanted to know more (Aug 2019 news). They found that, sans PILRA, microglia dialed down expression of transporters that shuttle lipids out of the cell, such as ABCA1 and ABCG1, and that they imbibed more ApoE.

2025年2月12日 · By 6 months, lipid staining revealed that microglia in these mice had 30 percent smaller lipid droplet area than control microglia. The FIT2-deficient microglia were not entirely devoid of droplets, in keeping with the protein primarily unleashing triglyceride-laden droplets. Other lipids, such as sterol esters, may still contribute.

2024年4月19日 · Microglia seem to play a hand in every aspect of Alzheimer’s pathogenesis, from the seeding and clearing of plaques to the traveling of tau to the dying of neurons. Scientists are pursuing therapeutics that both promote their neuroprotective functions and put the kibosh on their neurotoxic behavior.

2019年3月15日 · In 5XFAD animals, microglia again became hungrier for plaques in the auditory and visual cortices, as well as the hippocampus; this effect, too, extended to the mPFC. Plaque load fell by around two-thirds relative to controls in those brain regions, and by a third across the whole cortex. The microglia were more apt to cluster around plaques.

2025年3月14日 · Microglia also took on distinct signatures depending on the extent of amyloid clearance in their neighborhood. For example, in cases of extensive plaque clearance, the cells upregulated myristoylated alanine-rich C kinase substrate, a protein involved in cell motility and phagocytosis, and fibroblast growth factor receptor 3 in addition to ApoE.

2025年1月8日 · While many have long suspected that microglia were involved in the disease’s early stages, this study pinpoints their role in causing specific problems, such as impaired glucose metabolism, Nixon said. To his mind, the findings suggest microglia help drive NPC from the start, rather than simply mopping up after neurons become damaged.

2025年1月17日 · Microglia isolated from xenon-treated mice expressed a mix of homeostatic and MGnD genes, indicating they had assumed a state intermediate between the two. This expression profile resembled a “pre-MGnD” state that Butovsky and colleagues recently described, which compacted plaques, protected synapses, and improved cognition in mice ( Yin et ...

2019年9月4日 · Green believes microglia take up extracellular Aβ and induce it to aggregate inside themselves, thus seeding plaques. In support of this, the authors found Aβ aggregates lurking inside microglial lysosomes in 5xFAD and 3xTg mice. These microglia were often located far from plaques, making it unlikely the cells were simply ingesting plaque ...

First, Rosenzweig riled microglia by injecting fluorescently labeled apoptotic neurons directly into the brains of ApoE3- or ApoE4-knock-in mice, which only express the human isoforms of the protein. Rosenzweig sorted out microglia that had gobbled up the fluorescent, dying neurons, looking at what genes they expressed.