2022年5月2日 · In this study, we found that DA neurons in the mouse ventral tegmental area bidirectionally regulate the activity of 5-HT neurons in the dorsal raphe nucleus (DRN), with weaker stimulation...

4 天之前 · Excitatory monosynaptic LHb inputs to DRN trigger frequency-dependent indirect inhibition. We used a SERT-Cre::tdTom mouse line to conduct whole-cell electrophysiological recordings from ...

2022年7月21日 · Here, we found that glutamatergic projections from the lateral habenula (LHb) to the DRN were activated in male mice that experienced pre-exposure to a rival male mouse (“social instigation”)...

2024年12月10日 · Brain-wide c-Fos mapping experiment revealed that winner mice in the tube test competition exhibited a significantly higher number of c-Fos-positive neurons in the dmPFC downstream targets, including the DRN and PAG, whereas loser mice exhibited more c-Fos-positive neurons in the aBLA.

2022年8月17日 · To reveal the underlying patterns of neural activity, we visualized serotonergic neurons in the dorsal raphe nucleus (DRN 5-HT) of mice using miniaturized microscopy during diverse emotional behaviors.

2021年2月8日 · Emerging reports using mouse models have demonstrated that DRN DA neurons encode incentive salience and function in both incentive memory expression and sleep regulation. DRN DA neurons and their upstream inputs also contribute to the neural substrate of …

The dorsal raphe nucleus (DRN) represents one of the most sensitive reward sites in the brain. However, the exact relationship between DRN neuronal activity and reward signaling has been elusive. In this review, we will summarize anatomical, ...

2024年6月28日 · In the present study, we determined the specific impact of NA dysfunction on the physiology of DRN 5-HT and DRN DA neurons by pre-treating a group of mice with desipramine (DMI), a selective inhibitor of NA reuptake, before injecting 6-OHDA (DMI + 6-OHDA mice), which partially prevents striatal NA loss (Figure 3—figure supplement 1E).

The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been implicated in a wide variety of behavioral and neurological disorders. The DRN is subdivided into distinct anatomical subregions comprised of multiple cell types, ...

2025年1月2日 · The depressive-like behaviors were improved by activating DRN astrocytes in CSDS mice. Our results suggest that the astrocytes in DRN have an important role in depression and the findings offer new insights for the treatment of depression.