2019年12月13日 · In this study, we generated a human CRP transgenic reporter mouse, using a bacterial artificial chromosome (BAC)-based approach to include regions of the human CRP promoter linked with...

2014年4月24日 · To investigate CRP’s physiologies and their relationship with human pathological significance, it is essential to use appropriate animal models for translational research. The most popular models for the study of CRP are transgenic mice. However, researchers should be careful when extrapolating the findings derived from these animal models.

C-Reactive protein (CRP) is a minor acute phase reactant (APR) in the mouse, whereas CRP is the prototypical and one of the major positive APRs in all other mammals. MoCRP gene expression was tissue specific for the liver and induced …

C-reactive protein (CRP) is a plasma protein that is evolutionarily conserved, found in both vertebrates and many invertebrates. It is a member of the pentraxin superfamily, characterized by its pentameric structure and calcium-dependent binding to ...

2024年6月13日 · Moreover, endogenous CRP knockout in mice and rats, and human CRP complementation (intravenous injection and gene knock-in) showed consistent significant phenotypes in acute liver injury models that contribute significantly to complement activation.

2023年3月15日 · Despite the drastic differences in expression patterns, we have demonstrated an essential and conserved function of mouse, rat, and human CRP in acute inflammation, including liver failure and sepsis by careful control of experimental conditions and side-by-side comparison of mice and rats with or without KO of endogenous CRP or rescue of wild ...

A full-length C-reactive protein (CRP) cDNA clone has been isolated from a CBA/J-strain-mouse acute-phase liver library. The 1614-nucleotide cDNA specifies mRNA 5' and 3' untranslated regions of 81 and 858 bases respectively that flank 675 bases encoding mouse pre-CRP.

2011年2月25日 · To directly assess potential effects of CRP on atherogenesis, we have generated CRP-deficient mice via gene targeting and introduced the inactivated allele into atherosclerosis-susceptible ApoE−/− and LDLR −/− mice, two …

1993年7月1日 · C-Reactive protein (CRP) is a minor acute phase reactant (APR) in the mouse, whereas CRP is the prototypical and one of the major positive APRs in all other mammals. MoCRP gene expression was tissue specific for the liver and induced by culture supernatants of LPS-activated macrophages.

Human C-reactive protein (CRP), injected intravenously into mice or produced inside mice by a human transgene, protects mice from death following administration of lethal numbers of Streptococcus pneumoniae. The protective effect of CRP is due to reduction in the concentration of bacteria in the blo …