2016年4月11日 · Metrnl is a protein homologous to the neurotrophic factor Metrn. Although the expression and functions of Metrn have been explored extensively, studies on Metrnl are quite limited. In this...

2024年8月5日 · In this review, we present the predictive and therapeutic roles of Metrnl in various cardiovascular and metabolic diseases, including atherosclerosis, ischemic heart disease, cardiac remodeling, heart failure, hypertension, chemotherapy-induced myocardial injury, diabetes mellitus, and obesity.

Meteorin-like/Meteorin-Beta (Metrnl)/IL-41, also known as subfatin and cometin, is a small (~27kDa) secreted cytokine, protein encoded by a gene called meteorin-like (METRNL). [1] Lower serum levels of Metrnl might be a risk factor for developing coronary artery disease and type 2 diabetes mellitus [2] [3]

2025年3月30日 · METRNL (Meteorin Like, Glial Cell Differentiation Regulator) is a Protein Coding gene. Diseases associated with METRNL include Bladder Squamous Cell Carcinoma and Diabetes Mellitus . Gene Ontology (GO) annotations related to this gene include hormone activity .

发现在心肌梗死区域的髓系细胞中高表达metrnl蛋白。关于metrnl的研究主要是发现炎症过程中分泌，在应激条件下促进代谢适应和组织保护，但是metrnl的受体以及两者在心肌梗死修复过程中的作用仍是未知的。

Metrnl 是一种分泌蛋白，能够激活脂肪细胞、巨噬细胞、肌细胞和心肌细胞中不同的细胞内信号通路，具有白色脂肪组织 (BWT) 褐变、胰岛素敏感性、炎症抑制、骨骼肌再生和心脏保护等生理作用。

新型脂肪细胞因子Meteorin-like (Metrnl)是神经营养调节因子Meteorin (Metrn)的同源蛋白。 研究发现，Metrnl密切参与糖脂代谢性疾病，如血脂异常、肥胖、2型糖尿病、冠心病及非酒精性脂肪性肝病等的调控。 其机制可能与诱导米色脂肪形成、调节腺苷酸活化蛋白激酶 (AMPK)和过氧化物酶体增殖物激活受体δ/γ (PPARδ/γ)通路、激活WNT/β-连环蛋白 (β-catenin)通路有关。 因此，深入探讨Metrnl在糖脂代谢中的作用及机制，以期提高对脂肪细胞因子Metrnl的认识，有望使其成为治 …

Metrnl is a novel secreted protein homologous to the neurotrophin Metrn. But this protein, unlike Metrn that is mainly expressed in the brain, shows a relatively wider distribution in the body with high levels of expression in white adipose tissue and barrier tissues.

关键词: 镍纹样蛋白(Metrnl), 神经营养因子, 能量代谢, 胰岛素抵抗, 免疫调节. Abstract: Metrnl is a new cytokine with homologous orignination from neurotrophic factor Meteorin. Meanwhile, as a secreting protein, its gene and products show low tissue specificity and is widely expressed in different tissues of host.

Metrnl, also known as Meteorin-like, Meteorin-β, Subfatin, and Cometin, is a novel secretory protein that shares 46% amino acid sequence homology with a neurotrophic factor named Meteorin. Unlike Meteorin’s brain-specific expression in the central nervous system, Metrnl is abundant in metabolism-related organs and barrier tissues . Besides ...