Furthermore, menthol, a TRPM8 agonist, induced the dose-dependent release of histamine from RBL-2H3 cells. When TRPM8 transcripts were reduced by siRNA (small interfering RNA), menthol- and cold-induced Ca(2+) influx and histamine release were significantly reduced.

3 days ago · CDs have a polyhydroxy structure that can form hydrogen bonds with menthol and water molecules. Figure 11 A illustrates the number of hydrogen bonds formed by different hydroxyl oxygen atoms, clearly showing that the hydroxyl group at the C6 position forms more hydrogen bonds than those at the C2 and C3 positions. This may be attributed to the ...

Jul 29, 2020 · By imaging with fluorescent unnatural amino acid, we found that menthol binding induces wide-spread conformational rearrangements within the transmembrane domains.

Dec 1, 2013 · Menthol is a cyclic monoterpene alcohol which possesses well-known cooling characteristics and a residual minty smell of the oil remnants from which it was obtained. Because of these attributes it is one of the most important flavouring additives besides vanilla and citrus.

For the menthol/β‐citronellol system, the hydrogen bond formed by menthol as HBD is stronger than that of HBA. Unlike the menthol/acetic acid system, the relatively high fluctuations are encountered around the HBD interaction region, which illustrates that menthol O1 is more stable in constructing hydrogen bonds (half blue region).

Mar 25, 2022 · Menthol-based hydrophobic DESs have lower viscosity and higher volatility than hydrophobic quaternary-ammonium based DESs 5. Furthermore, it is easy to recover target compounds from menthol...

Jan 1, 2025 · DESs were produced by mixing DL-menthol (hydrogen bond acceptor, HBA) with pyruvic acid (Pyr) and levulinic acid (Lev) (hydrogen bond donors, HBD). The densities of DESs were similar to ESBO and DEHP and exhibited low viscosity and shear-thinning behavior.

Menthol is an organic compound, specifically a monoterpenoid, that occurs naturally in the oils of several plants in the mint family, such as corn mint and peppermint.It is a white or clear waxy crystalline substance that is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1R,2S,5R) configuration.

Jan 30, 2025 · menthol, terpene alcohol with a strong minty, cooling odour and taste. It is obtained from peppermint oil or is produced synthetically by hydrogenation of thymol. Menthol is used medicinally in ointments, cough drops, and nasal inhalers. It is also used as flavouring in foods, cigarettes, liqueurs, cosmetics, and perfumes.

Menthol and its derivatives are widely used in pharmaceutical, cosmetic and food industries. Among its eight isomers, (single bond)-menthol is the most effective one in terms of refreshing effect. While the invigorating property of (single bond)-menthol is generally known, this claim is based on a substantial amount of literature and experience.