2016年2月24日 · From wikipedia: "Memantine is a low-affinity voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptors. By binding to the NMDA receptor with a higher affinity than Mg2+ ions, memantine is able to inhibit the prolonged influx of Ca2+ ions, particularly from extrasynaptic receptors, which forms the basis of neuronal excitotoxicity.

Memantine isn't very long term memory impairing, in comparison to DXM, or even Ketamine, but short term memory does seem to suffer a bit and you can lose trains of thought quite easily at high doses. It's clean feeling, compared to DXM.

“Memantine was started at 5 or 10 mg QHS, before being increased by 5 or 10mg every 4-7 days, as tolerated, to a maximum dose of 40 mg - 60 mg, as tolerated. In all, 13 patients showed complete remission from CRPS with VAS 0 and the disappearance of allodynea for at least nine months after the use of memantine.

2015年6月15日 · Memantine is obviously one of the safer NMDA antagonists, but it has still been noted to cause vacuolation and neuronal damage at high doses in rodents. The toxic dose in humans is not known, but extrapolating from the therapeutic-to-toxic ratio in rodents, you are definitely flirting with this toxicity.

Memantine is a dissociative, particularly during the startup phase, so it's not surprising that you would feel distanced from anxiety and depression. That doesn't make it a good treatment, though, as there's a massive difference between masking an underlying disorder and actually treating it …

When I get over these few bad things about memantine, the dissociative effects become somewhat more enjoyable. Music sounds better than ever, I constantly think back on life under a more positive light and make life changing decisions ( never follow-up with those of course :D).

2017年8月18日 · "The main finding of this study therefore, is that mice trained-on memantine to one platform location are later impaired in spatial learning when trained-off memantine, introducing the possibility that spatial learning for platform locations acquired when training-on memantine inhibited learning in subsequent trainingoff the drug.

I have experience with memantine at various doses, and I'll admit the positive cognitive benefits vary greatly between individuals and finding the proper dosage is key. The biggest hurdle is the one to two week adjustment period when starting, which presents a …

2015年4月10日 · Just an FYI, brain-fog is a very normal immidiate reaction to Memantine every time you increase the dose. Memantine is an anticholinergic, it blocks certain acetylcholine receptors. These receptors upregulate fairly rapidly however, and so generally within a week of a dose increase the brain-fog should dissipate.

2022年10月29日 · I don’t have BPD but struggle with many of the core features. I had improvement on memantine and some of the benefits are sticking around even 1 months after my last cycle. If you’re in a good place— take advantage of the emotional stability on memantine and dive deep into therapy. Memantine let me talk about major trauma in a calm way.