Melperone (Bunil , Buronil (AT, BE, CZ, DK, FI †, NL †, NO †, SE), Eunerpan ) [3] is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol. It first entered clinical use in 1960s.

Melperone is an atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients.

盐酸美哌隆: 一种DRDs拮抗剂药物，目前全球最高研发状态为批准上市，作用机制: DRDs拮抗剂 (多巴胺受体家族拮抗剂)，治疗领域: 神经系统疾病，在研适应症: 精神分裂症。

2021年5月29日 · Melperone is a low-potency antipsychotic and a butyrophenone derivative that is classified as an SGA. It has been used in clinical practice since the 1960s (Röhricht et al. 2012). The bioavailability of levomepromazine is 50–60%, and the plasma half-life has been reported to range between 15 and 30 h (Dahl 1976).

具有抗组织胺H1受体的作用，对中枢神经有较强的抑制作用，还有阿托品样作用。 适用皮肤粘膜的过敏性疾病，如荨麻疹、枯草热，过敏性鼻炎等。 还可用于预防晕船、晕车、晕飞机等晕动病。 思睡、口干为其主要不良反应。 3.乳膏剂：20g。 为乙醇胺的衍生物，抗组胺效应不及异丙嗪，作用持续时间也较短，镇静作用两药一致。 也有局麻、镇吐和抗M-胆碱样作用。 （3）镇咳作用：可直接作用于延髓的咳嗽中枢，抑制咳嗽反射。 口服吸收完全，tmax为2h，维持4～6h，消除 …

Melperone is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol. Melperone has been used for a span of greater than 30 years in the European Union.

Melperone is a butyrophenone-antipsychotic with a low tendency to cause extrapyramidal side effects. It shows weak affinity for the dopamine receptors and its main antipsychotic properties seem to result from its higher 5-HT2A receptor affinity, hence described in the literature as an atypical antipsychotic.

2003年1月1日 · Melperone, a butyrophenone, has been shown to possess atypical antipsychotic properties, i.e. ability to produce an antipsychotic effect in man at doses that cause minimal extrapyramidal side effects.

"Melperone, an atypical antipsychotic drug, in the treatment of schizophrenia: dose-response analysis on effectiveness and tolerability, and efficacy for treatment-resistant schizophrenia and cognitive function".

D08172 Melperone hydrochloride Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Dopamine DRD2 D08172 Melperone hydrochloride Drug groups [BR:br08330] Neuropsychiatric agent DG03200 Antipsychotic agent DG01940 Butyrophenone derivative DG00887 Melperone. BRITE hierarchy ...