Melanins and melanogenesis: from pigment cells to human …
Melanins and melanogenesis: Elucidating chemical and physical properties is central to unravel biological roles and functions and to translate clues from pigment cells to innovative applications.
Melanins and melanogenesis: methods, standards, protocols
2013年5月25日 · One possible way to evaluate the role of melanin in preserving cell membrane lipids from UV-A-induced peroxidation is the selective modulation of melanin synthesis by tyrosine supplementation. In murine melanocytes with different melanization (e.g., black, brown), melanogenesis was stimulated by increasing tyrosine up to 200 μM.
Melanin’s Journey from Melanocytes to Keratinocytes ... - MDPI
2023年7月10日 · There are two types of melanin: black/brown eumelanin and yellow/red pheomelanin [8, 9]. These are synthesized in melanocytes within melanosomes, which are lysosome-related organelles (LROs), as they are endosomal-derived, contain lysosomal markers, and are acidic in the early stages of their biogenesis [10].
Natural Melanin: Current Trends, and Future Approaches, with …
Melanin is a universal natural dark polymeric pigment, arising in microorganisms, animals, and plants. There is a couple of pieces of literature on melanin, each focusing on a different issue, the goal of the present review is to focus on microbial melanin. It …
A genome-wide genetic screen uncovers determinants of human …
By exploiting melanin’s light-scattering properties, we conducted a genome-wide screen and uncovered genes regulating melanin content and hence, melanogenesis, in human cells. These melanin-promoting genes are expressed at higher levels in darkly pigmented melanocytes and show association with pigmentation in human populations.
Melanin/melanin-like nanoparticles: As a naturally active platform …
2023年12月1日 · Melanin and melanin-like nanoparticles possess intrinsic NIR absorption, making them promising candidates for PAI-guided treatment of multiple diseases. PAI technology provides a new method for the early detection and treatment of tumors by studying the morphological structure, functional metabolism, physiological and pathological ...
Synthesis and physiological implications of melanic pigments
The process of melanin synthesis and distribution is called melanogenesis, a process that is based on melanocytes present among the basal cells of the epidermis. Pigments formed in melanocyte melanosomes are then stored in the basal layer of ...
Melanoma, Melanin, and Melanogenesis: The Yin and Yang …
The role of melanin and of impairment of melanin synthesis in the initiation and progression of melanoma. The defective melanin synthesis in connection with external factors (UV) and genetic predispositions plays a role in melanomagenesis in a positive feedback loop.
Melanins: Skin Pigments and Much More—Types, Structural …
2014年3月18日 · Melanin is frequently considered just an animal cutaneous pigment and is treated separately from similar fungal or bacterial pigments. Similarities concerning the phenol precursors and common...
Melanoma, Melanin, and Melanogenesis: The Yin and Yang
2022年3月14日 · While the presence of melanin protects against the development of skin cancers including cutaneous melanoma, its presence may be necessary for the malignant transformation of melanocytes. This shows a complex role of melanogenesis in melanoma development defined by chemical properties of melanin and the nature of generating pathways such as eu ...