Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene. [5] [6] [7]

mapk（丝裂原活化蛋白激酶）通路有三级的信号传递过程：mapk，mapk激酶（mek或mkk）以及mapk激酶的激酶（mekk或mkkk）。这三种激酶能依次激活，共同调节着细胞的生长、分化、 …

2020年11月11日 · Here, the authors report the MEKK2 is a key mediator of this aberrant ERK activation and that MEKK2 inhibitors, including ponatinib, ameliorate skeletal defects in a …

2018年4月17日 · Here we show that MEKK2 (MAP3K2) and MEKK3 (MAP3K3) inhibit GLI1 transcriptional activity and oncogenic function through phosphorylation on multiple Ser/Thr …

2020年4月8日 · Disruption of this kinase cascade leads to activation of SUMM2-mediated immune responses. MEKK2, a close paralog of MEKK1, is required for defense responses mediated by …

利用mekk2 ko小鼠，我们发现：1、细菌感染可以激活mekk2。2、ko小鼠对内毒素引起的感染性休克有缺陷。3、李斯特菌感染后，ko 巨噬细胞生成细胞因子较少。因此，mekk2可能在抗菌感 …

2013年9月27日 · MEKK2 (MAP/ERK kinase kinase-2) is a serine/threonine kinase that belongs to the MEKK/STE11 family of MAP kinase kinase kinases (MAP(3)Ks). MEKK2 integrates stress …

In this study, we showed that MEKK2 serves as a negative regulator of MPK4. It binds to MPK4 to directly inhibit its phosphorylation by upstream MKKs. Activation of SUMM2-mediated defense …

2010年6月29日 · Here, we report that CHIP is a negative regulator of the MEKK2‐ERK pathway in hyperosmotic stress response. MEKK2 was activated by treating cells with sorbitol …

2011年2月25日 · Here we show that MEKK2 and MEKK3 deficiency in T cells resulted in hypersensitivity to the TGF-β signaling during iTreg and Th17 cell differentiation. We …