Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. [5] It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.

Butanone, also known as methyl ethyl ketone (MEK) or ethyl methyl ketone, [a] is an organic compound with the formula CH 3 C (O)CH 2 CH 3. This colorless liquid ketone has a sharp, sweet odor reminiscent of acetone. It is produced industrially on a large scale, but occurs in nature only in trace amounts. [7]

2015年9月24日 · New drugs that inhibit RAF or MEK1 and MEK2 have recently been approved or are currently undergoing late-stage clinical evaluation. In this Review, we consider the ERK pathway, focusing...

2012年1月6日 · MEK1/2 are dual-specificity protein kinases that mediate the phosphorylation of tyrosine and then threonine in ERK1 or ERK2, their only known physiological substrates. This phosphorylation activates ERK1/2, which are protein-serine/threonine kinases.

2-Butanone is a manufactured chemical but it is also present in the environment from natural sources. It is a colorless liquid with a sharp, sweet odor. It is also known as methyl ethyl ketone (MEK). 2-Butanone is produced in large quantities.

A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase enzymes MEK1 and/or MEK2. They can be used to affect the MAPK/ERK pathway which is often overactive in some cancers.

2012年1月6日 · MEK1 and MEK2 are related protein kinases that participate in the RAS-RAF-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes including apoptosis, cell cycle progression, cell migration, differentiation, metabolism, and proliferation.

2025年3月30日 · MAP2K2 (Mitogen-Activated Protein Kinase Kinase 2) is a Protein Coding gene. Diseases associated with MAP2K2 include Cardiofaciocutaneous Syndrome 4 and Cardiofaciocutaneous Syndrome. Among its related pathways are Prolactin Signaling and IL-9 Signaling Pathways.

2004年11月14日 · MEK1 and MEK2 are dual-specificity protein kinases that phosphorylate the downstream target ERK on specific tyrosine and threonine residues. The MEKs function as a key component of this...

In this Review, we consider the ERK pathway, focusing particularly on the role of MEK1 and MEK2, the 'gatekeepers' of ERK1/2 activity. We discuss their validation as drug targets, the merits of targeting MEK1 and MEK2 versus BRAF and the mechanisms of action of different inhibitors of MEK1 and MEK2.