2014年9月24日 · There is a clear overlapping in substrate selectivity between mEH and sEH; however, sEH is generally complementing mEH in its xenobiotic-metabolizing activity. Comparatively, the regulating function of sEH in the metabolism of fatty acid-derived epoxides mediators is considered more biologically important (Decker et al. 2009 ).

These isozymes are known (mEH and sEH) or presumed (EH3 and EH4) to share a common structure that includes containing an Alpha/beta hydrolase fold and a common reaction mechanism wherein they add water to epoxides to form vicinal cis (see (cis-trans isomerism); see (epoxide#Olefin (alkene) oxidation using organic peroxides and metal catalysts ...

2021年1月21日 · Both mEH and sEH contribute to metabolism of AA-, EPA- and DHA-derived epoxides to generally less biologically active diols in vivo. In contrast, sEH is the dominant hydrolase for LA-derived epoxides in vivo. A significant role of mEH in EpFA hydrolysis and cardiovascular physiology has only become evident in recent years [7, 8].

2017年10月3日 · Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions.

Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions.

2014年1月10日 · epoxidehydrolase,mEH)与多种癌症易感性相关联；可溶性环氧化物水解酶(solubleepoxidehydrolase, sEH)在心肌肥大、糖尿病、高血压等疾病的治疗中起着重要作用。 本文主要综述了mEH和sEH的分子

2009年10月6日 · In line with this, the two best-investigated EHs, soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH), show highest expression in human and murine liver and lower levels in multiple other organs including the brain (Oesch et …

Epoxide hydrolases (EH), enzymes present in all living organisms, transform epoxide-containing lipids to 1,2-diols by the addition of a molecule of water. Many of these oxygenated lipid substrates have potent biological activities: host defense, control of development, regulation of blood pressure, inflammation, and pain.

2021年1月21日 · In vitro, mEH metabolizes most EpFAs at a far slower rate than soluble epoxide hydrolase (sEH) and has thus been generally considered to exert a minor role in EpFA metabolism in vivo. Indeed, sEH inhibitors or sEH-deficiency increase EpFA levels and are protective in animal models of cardiovascular disease.

CUDA 是一种有效的可溶性环氧水解酶 (sEH) 抑制剂，对小鼠 sEH 和人 sEH 作用的 IC 50 分别为 11.1 nM 和 112 nM。 CUDA 能选择性地上调过氧化物酶体增殖激活受体 PPARalpha 的活性。