Minichromosome maintenance - Wikipedia
MCM2-7 is required for both DNA replication initiation and elongation; its regulation at each stage is a central feature of eukaryotic DNA replication. [3] During G1 phase, the two head-to-head …
Nature | 微小染色体维持蛋白在维持基因组复制稳定性中重要作用
2020年11月30日 · 微小染色体维持蛋白 （Minichromosome maintenance proteins, MCM）是DNA依赖性ATPase，可与复制起点结合并支持DNA复制。 大量MCM2-7在G1期的染色质上 …
Role of MCM2–7 protein phosphorylation in human cancer cells
2018年7月24日 · A heterohexameric complex composed of minichromosome maintenance protein 2–7 (MCM2–7), which acts as a key replicative enzyme in eukaryotes, is crucial for initiating …
Cell：我国科学家领衔解析出人类MCM2-7复合物的三维结构，有 …
2023年1月15日 · 这项新研究的结果提供了人类起始前复合物---MCM2-7复合物---的高分辨率结构和机理信息，将来可用于开发靶向MCM2-7复合物的无毒抗癌药物。
MCM基因家族 - 知乎
2022年4月19日 · MCM基因家族包括MCM2~7六个成员，广泛存在于包括从酵母到人类等真核生物中，具有调控细胞分裂的作用。 MCM名称来源为minichromosome mantenance，即微小染色 …
MCM2-7 complex is a novel druggable target for neuroendocrine …
2021年6月25日 · Inhibition of MCM2-7 by treatment with ciprofloxacin inhibits NEPC cell proliferation and migration in vitro, significantly delays NEPC tumor xenograft growth, and …
The MCM2-7 Complex: Roles beyond DNA Unwinding - MDPI
2024年3月6日 · The MCM2-7 complex is a hexameric protein complex that serves as a DNA helicase. It unwinds the DNA double helix during DNA replication, thereby providing the single …
The Mcm Complex: Unwinding the Mechanism of a Replicative Helicase
Summary: The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. …
Assembly, Activation, and Helicase Actions of MCM2-7: Transition …
MCM2-7, evolutionarily conserved and essential for DNA replication, functions as the central factor for the eukaryotic replicative DNA helicase. Here, we summarize the roles of MCM2-7 in …
The assembly of the MCM2-7 hetero-hexamer and its significance …
2023年6月28日 · The mini-chromosome maintenance proteins 2-7 (MCM2-7) hexamer is a protein complex that is key for eukaryotic DNA replication, which occurs only once per cell cycle. To …