Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene. [5][6] The protein encoded by this gene belongs to the Bcl-2 family. …

2021年9月2日 · Here, we synthesize studies characterizing MCL1s influence on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to …

Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is …

2024年12月25日 · MCL1 (MCL1 Apoptosis Regulator, BCL2 Family Member) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Hematologic Cancer. …

2020年1月6日 · MCL1 is the first antiapoptotic gene for which homology to BCL2 was reported. Mcl-1 plays a significant role in the inhibition of apoptosis and demonstrates oncogenic …

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control, promoting cell survival by interfering at an early stage in a cascade of events leading to release of …

2021年9月30日 · Myeloid cell leukemia 1 (MCL-1) is an anti-apoptotic oncoprotein and one of the most investigated members of the BCL-2 family. It is commonly known to be genetically …

2020年5月5日 · We report that MCL-1 Matrix functions to preserve mitochondrial energy transduction and improves respiratory chain capacity by modulating mitochondrial oxygen …

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control, promoting cell survival by interfering at an early stage in a cascade of events leading to release of …

In this study, using splice-switching antisense oligonucleotides (ASOs), we increased the synthesis of Mcl-1S, which induced a concurrent reduction of Mcl-1L, resulting in increased …