2025年3月30日 · MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11) is a Protein Coding gene. Diseases associated with MAP3K11 include Dementia and Gastric Cancer. Among its related pathways are Signaling downstream of RAS mutants and G-protein signaling RAC1 in cellular process.

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene. [5][6] The protein encoded by this gene is called MLK3 and it is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a …

MAP3K11 as a candidate gene for left ventricular hypertrophy High MLK3 phosphorylation promotes invasion of colorectal cancer. This study identified two distinct peptide-binding sites in the SH3 domain of MLK3, providing critical insights into mechanisms of ligand binding by the mixed-lineage kinase family of kinases.

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7.

该激酶包含一个 SH3 结构域和一个亮氨酸拉链基序。 该激酶优先激活 MAPK8/ JNK 激酶，并作为 JNK 信号通路的正调节剂发挥作用。 该激酶可直接磷酸化并激活 IkappaB 激酶 alpha 和 beta， …

Results: Utilizing engineered tumour models we identified MAP3K11/GDF15 pathway activation as a potent inducer of cancer cachexia. Increased expression and high circulating levels of GDF15 acted as a key mediator of this process.

2023年6月7日 · Increased HIV-1 transcription by MAP3K11 is dependent on its kinase activity, and the corresponding MAP3K11 siRNA reduces HIV-1 infection by 40% . Several MAP3Ks that regulate IFN-I signaling have been identified; however, each host MAP3K has a unique set of functions that vary depending on the virus and cell type.

Title: MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma.

2024年8月27日 · MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma. The role of mixed lineage kinase 3 (MLK3) in cancers. Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division.

Ubiquitous expression in fat (RPKM 13.9), brain (RPKM 10.1) and 22 other tissues. 该基因编码蛋白激酶家族的一个成员，这些蛋白激酶参与多种细胞过程的生化信号整合，包括细胞增殖、分化、转录调节和发育。 编码的蛋白质可以被促炎细胞因子和环境压力激活，通过有丝分裂原活化蛋白激酶激酶 (MKK) 的磷酸化。 可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 3 月]