MALDI mass spectrometry imaging (MALDI-MSI) is the use of matrix-assisted laser desorption ionization as a mass spectrometry imaging [2] technique in which the sample, often a thin tissue section, is moved in two dimensions while the mass spectrum is recorded. [3]

2015年1月26日 · In this current review, we discuss the state-of-the-art for MALDI Imaging mass spectrometry, its recent applications to analyze tissue specimen, the contributions in understanding...

2025年1月14日 · Matrix-assisted laser Desorption/Ionization Mass Spectrometry Imaging (MALDI MSI) is an analytical technique used for the spatial mapping of drugs, explosives, and organic samples, making it a game-changer in Forensic examination.

Quantitative MSI (qMSI) has typically been challenging to achieve because of matrix and tissue heterogeneity, inefficient analyte extraction, and ion suppression effects, but recent studies have demonstrated approaches to obtain highly robust methods and reproducible results.

2024年6月1日 · Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI), traditionally used for analyzing larger molecules, faces challenges with low molecular weight (LMW) compounds (m/z < 500) due to matrix interference in the lower mass range.

Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF)-profiling and imaging mass spectrometry (MSI) are promising technologies for measuring hundreds of different molecules directly on tissues.

2022年2月2日 · MALDI-MSI is a label-free, innovative, and emerging technique that produces two-dimensional (2D) ion density maps representing the distribution of an analyte(s) across a tissue section in relation to tissue histopathology.

MALDI-MS is a valuable analytical tool in pathology and laboratory medicine. Advantages of MALDI-MS include ease of sample preparation and analysis. Uses include ID of pathogens, monoclonal proteins, variants and diseased tissue.

2024年9月1日 · Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a label-free tissue-based throughput analytical technology for the qualitative and quantitative spatial analyses of biomolecules, such as proteins and peptides, lipids, drug molecules and/or their metabolites.

2022年2月3日 · Here, we aim to provide a comprehensive review of MALDI-MSI with an emphasis on its advances of the instrumentation, methods, application, and future directions in single cell and biological tissues. Keywords: imaging mass spectrometry; matrix-assisted laser desorption/ionization (MALDI); proteomics; single-cell metabolomics; spatial ...