Monocyte and macrophage differentiation: circulation inflammatory …
Although much more evidence supports that Ly6C + and CD14 + CD16-classical monocytes are pro-inflammatory monocytes, their high expressions of CD62L imply a possible role of lymph node migration and differentiate into a variety of macrophages and dendritic cell subtypes that could inhibit immune response . Understanding the functions of subsets ...
CD14 is a decision-maker between Fas-mediated death and inflammation
2024年9月24日 · Our findings propose CD14 as a crucial chaperone of Fas receptor internalization in macrophages and neutrophils, resulting in Cd14−/− myeloid cells that are protected from FasL-induced apoptosis, activate nuclear factor κB …
Pharmacological validation of targets regulating CD14 during macrophage …
Pro-inflammatory macrophage differentiation remains a process facilitating a broad array of disease pathologies, and has recently emerged as a potential target against cytokine storm in COVID19. Here, we perform a whole-genome CRISPR screen to identify essential nodes regulating CD14 expression in myeloid cells, using the differentiation of THP ...
Pharmacological validation of targets regulating CD14 during macrophage …
2020年10月7日 · Here, a whole-genome CRISPR/ Cas9 screen was performed in human THP-1 cells to understand which genes regulate the differentiation of inflammatory macrophages, based on changes in CD14 expression. We identified genes that downregulated CD14 after differentiation of THP-1 cells with PMA and others that promoted differentiation by …
Pharmacological validation of targets regulating CD14 during macrophage …
The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory macrophage function. Pro-inflammatory macrophage differentiation remains a process facilitating a broad array of disease pathologies, and has recently emerged as a potential target against cytokine storm in COVID19.
Multifaceted role of CD14 in innate immunity and tissue …
2023年12月1日 · CD14 is a co-receptor of Toll-like receptor (TLR)− 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage-associated molecular patterns, thereby facilitating inflammatory immune responses.
The response of two polar monocyte subsets to inflammation
2021年7月1日 · It has been shown that, according to primary pro-inflammatory polarization markers, their cytokine profile, and their phagocytic activity, macrophages derived from CD14+ monocytes exhibit higher sensitivity to inducers of pro-inflammatory polarization.
CD14 is critical for TLR2-mediated M1 macrophage activation …
2017年8月1日 · We demonstrated here that, in the presence of CD14, ArtinM induces an inflammatory profile in macrophages with robust iNOS2 expression, NO production, and IL-12 production, accompanied by IL-10 release.
Macrophage CD14 impacts immune defenses against influenza …
CD14 on macrophages may play a central role in mediating inflammation during asthma and influenza through direct interaction with viral and allergen antigens via CD14/TLR4 pathways or through indirect activation through mediators in the microenvironment that become available during viral pathogenesis and allergen sensitization.
Role of CD14 in human disease - Sharygin - Wiley Online Library
Canonically, the CD14 glycoprotein receptor has been shown to promote macrophage activation upon binding either LPS or oxidized lipids. CD14 was initially recognized as a membrane receptor for lipopolysaccharides (LPS) on macrophages and to mediate their host cytokine response to sepsis, most notably TNF [1].