巨噬细胞极化标志物 - 知乎 - 知乎专栏
2023年12月26日 · m2a巨噬细胞：由il-4或il-13活化。il-4反过来促进甘露糖受体（cd206）的表达。经证实，进一步上调 il-10、tgf-b、ccl17、ccl18和ccl22能促进细胞生长、组织修复和胞吞作用。 m2b巨噬细胞：由免疫复合物、toll样受体（tlr）配体和il-1b活化。
Metabolic heterogeneity of tissue-resident macrophages in
2023年9月12日 · The metabolic profiles of CD11c + and CD206 + macrophages appeared to be a consequence of the tissue environment, as direct comparisons of these populations between both intestine sites showed...
A flow cytometry approach reveals heterogeneity in ... - Nature
2021年6月24日 · In vitro polarization of bone marrow-derived macrophages (BMDM) into M1- and M2-like cells suggested functional distinction of CD86 + MHCII + CD206- and CD206 + cells. Combination of both...
Depletion of CD206+ M2-like macrophages induces fibro …
2022年11月21日 · We show that depletion of CD206 + M2-like macrophages activates FAPs and activated FAPs secrete follistatin, a promyogenic factor, thereby boosting the recovery process. Conversely, deletion of...
Targeting CD206 + macrophages disrupts the establishment of a …
2024年11月27日 · CD206 is a common marker of a putative immunosuppressive “M2” state in tumor-associated macrophages (TAMs). We made a novel conditional CD206 (Mrc1) knock-in mouse to specifically visualize and/or deplete CD206 + TAMs.Early depletion of CD206 + macrophages and monocytes (Mono/Macs) led to the indirect loss of conventional type I dendritic cells (cDC1), CD8 T cells, and NK cells in tumors.
CD206+ M2-Like Macrophages Are Essential for Successful …
2020年10月22日 · Macrophages (MΦs) play important roles in implantation. Depletion of CD11b+ pan-MΦs in CD11b-diphtheria-toxin-receptor (DTR) mice is reported to cause implantation failure due to decreased progesterone production in the corpus luteum. However, of the M1 and M2, the type of MΦs that is important for implantation is unknown.
Mannose receptor (CD206) activation in tumor-associated macrophages ...
Flow cytometry experiments with CD11b + F4/80 + Gr1 − macrophages gated on alive cells using the M1 marker CD86 and M2 marker CD206 showed rapid induction of CD86 expression with an increase in the CD86 + CD206 + double-positive macrophage fraction (87.8% versus 10.3% in vehicle-treated control) within 30 min of starting treatment with RP-182 ...
CD206+/MHCII− macrophage accumulation at nerve injury site …
2022年12月1日 · In in vitro experiments, TASTPM bone marrow-derived macrophages showed efficient phagocytosis of myelin extracts containing amyloid precursor protein, acquired CD206 + /MHCII − phenotype, upregulated mRNA expression of proenkephalin (PENK) and accumulated enkephalins in culture media.
JCI Insight - CD206+ tumor-associated macrophages cross …
2022年5月3日 · We show that CD11b+CD206+ TAM represent the dominant tumor-infiltrating myeloid cell population, expressing a unique cell surface repertoire, promoting Ag cross-presentation and Ag-specific CD8+ T cell activation comparable with …
M1 and M2 Macrophage Markers - OriGene
CD11b: CD11b, or integrin alpha M, is a transmembrane glycoprotein primarily expressed on the surface of myeloid cells, including macrophages. CD11b involves cell adhesion, migration, phagocytosis, and immune response. While CD11b is not a specific marker for M2 macrophages, it is expressed on M1 and M2 macrophages and other myeloid cells.
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